USING ACYCLOVIR TO PREVENT UVB LIGHT REACTIVATION OF HERPES SIMPLEX

紫外光(UVB)已被证明可以诱导细胞重新激活 既往复发的非生殖器区域的单纯疱疹病毒 被观察到了。这项研究的目的是评估 阿昔洛韦抑制单纯疱疹病毒复发的诱导作用 被UVB光感染。患者将被随机分成一个周期 接受阿昔洛韦或安慰剂口服6天的放射治疗 双盲研究。每个周期将由四次挑战照射组成 使用四种模拟红斑剂量的UVB光。每个病人都会 ，以记录紫外线照射或紫外线照射引起的复发皮损 在整个研究过程中自发发生的损害。 阿昔洛韦已被证明对疼痛、皮损有显著效果 使用时结痂、皮损愈合和病毒外壳 静脉注射。它还被证明在 局部用药可缓解疼痛、瘙痒和病毒引流时间 管理。口服，而不是静脉注射或局部使用阿昔洛韦 在这项研究中专门使用。皮肤靠近但不靠近的皮肤区域 以前与疱疹复发有关的重叠部位将是 被选中了。将使用模板来隔离四个直径为1厘米的 皮肤的区域。一种可以容纳四个荧光灯管的特殊装置 在距离目标地点25.4厘米的地方将被利用。这个 荧光灯管的输出将主要是UVB(290-320 nm)，带有 减少UVA(320-400 nm)高加索人皮肤平均色素沉着 需要大约四分钟的曝光时间，需要增加黑色素 更多的曝光时间。

Ultraviolet light (UVB) has been demonstrated to induce reactivation of Herpes Simplex Virus in non-genital areas in which prior recurrences had been observed. The purpose of this study is to evaluate the ability of acyclovir to suppress the induction of recurrent Herpes Simplex Virus infection by UVB light. Patients will be randomized on a cycle of radiation to receive oral acyclovir or placebo pills for six days in a double-blind study. Each cycle will consist of four challenge irradiations with four miminal erythematous doses of UVB light each. Each patient will be followed for documentation of recurrent lesions induced by UVB light or spontaneously occuring lesions throughout the course of the study. Acyclovir has been shown to have significant effects on pain, lesion crusting, lesion healing and viral sheading when administered intravenously. It has also been shown to have significant efficacy in relief of pain, itching and viral sheading time when topically administered. Oral as opposed to intravenous or topical acyclovir will be used exclusively in this study. An area of skin which is near but not overlapping sites previously involved with herpetic recurrence will be selected. A template will be utilized to isolate four 1 cm in diameter areas of skin. A special apparatus which can hold four fluorescent tubes at a distance of 25.4 cm from the target site will be utilized. The fluorescent tubes will have output primarily of UVB (290-320 nm) with a reduced output of UVA (320-400 nm) average caucasian skin pigmentation would call for about four minutes exposure with increased melanin requiring more exposure time.