Developmental Clinical Studies - Phase 1 studies on an analogue of peptide YY as a treatment for obesity

当人类进食时，肠道会自然分泌化学物质进入血液，使人感到饱腹，从而停止进食。其中一种化学物质被称为肽YY（PYY）。我们之前已经证明，注射人PYY会降低食欲和食物摄入量。我们现在已经开发出一种非常相似的化学物质Y242，用于治疗肥胖症。Y242已经在动物身上进行了测试，并已被证明是安全的，并降低他们的食欲。这项研究将测试Y242在人体中的安全性和耐受性。

When humans eat, the bowels naturally secrete chemicals into the bloodstream which make people feel full and which stop eating. One of these chemicals is known as Peptide YY (PYY). We have previously shown that injections of human PYY reduce appetite and food intake. We have now developed a very similar chemical, Y242, as a treatment for obesity. Y242 has been tested in animals and has been shown to be safe, and to reduce their appetite. This study will test Y242 for its safety and tolerability in humans.