Effect of Inorganic Nitrite on Cardiac and Skeletal Muscle: Physiology, Pharmacology and Therapeutic Potential

食用绿色蔬菜和甜菜根会增加血液中一种叫做亚硝酸盐的化学物质的浓度。最近的证据表明，当这种化学物质的浓度通过饮食方式增加时，肌肉的工作效率更高，需要的氧气更少。我们将研究为什么会发生这种情况。心肌是另一种类型的肌肉，我们将研究亚硝酸盐是否在心肌中具有类似的作用。最后，我们将研究这是否可以作为一种治疗疾病，如腿部和心脏动脉阻塞。

Consumption of green vegetables and beetroot increases the concentration in the bloodstream of a chemical called nitrite. Recent evidence suggests that when the cncentration of this chemical is increased by dietary means muscle works more efficiently and requires less oxygen. We will investigate why this occurs. Heart muscle is another type of muscle and we will investigate whether nitrite has a similar effect in heart muscle. Finally we will investigate whether this can be exploited as a treatment in conditions such as blockage of the arteries of the leg and the heart.