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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES

IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
裂殖子侵入红细胞受体的鉴定
批准号：
4688411
负责人：
L H MILLER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4688411
关键词：
Plasmodium knowlesi acidity /alkalinity cellular immunity communicable disease transmission erythrocytes human tissue malaria microorganism immunology protozoal antigen virulence

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中文摘要
翻译
裂殖子以受体特异性方式与红细胞相互作用 表面，是免疫力可以阻止的阶段 入侵 因此，裂殖子表面组分因其 在红细胞识别中的作用和作为诱导保护性 免疫力 我们现在正在研究裂殖子表面的一种抗原， 经历抗原变异以了解其分子基础 变化量 我们正在生产恶性疟原虫突变体，它使用一种替代受体， 入侵人类红细胞和继续研究达菲血液 间日疟原虫入侵受体的一组分子。
英文摘要
The merozoite interacts in a receptor specific manner with the erythrocyte surface and is the stage against which immunity may work to block invasion. Thus, merozoite surface components are of interest for their role in erythrocyte recognition and as antigens for induction of protective immunity. We are now studying one antigen on the merozoite surface that undergoes antigenic variation to understand the molecular basis for this variation. We are producing P. falciparum mutants that use an alternate receptor for invasion of human red cells and continuing the study of the Duffy blood group molecule that is the receptor for P. vivax invasion.
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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES