DISPOSITION OF HALOGENATED DIBENZOFURANS

卤代二苯并呋喃在世界范围内被发现是环保的 污染物。与其他卤代芳香族化合物结构相关 外源生物的毒性和处置似乎随着程度的不同而不同 和卤化的位置。这项工作已经确立了 2，3，7，8-四氯二苯并呋喃(TCDF)是一种剧毒的异构体。 只有在新陈代谢后才排泄出来，与毒性成反比 新陈代谢能力。大鼠产生的TCDF的代谢物是 被特色化的。似乎有一个身体负担的门槛 毒性。在母体分娩后，检查胎儿的分布情况。 曝光。身体成分在人格特质中的作用 2，3，7，8-四氯二苯并二恶英(TCDD)，毒性最大的人造化合物 已知的，正在对敏感的同源小鼠品系进行检测 耐TCDD毒性。八氯二苯并对二恶英的吸附 来自胃肠道的强迫症(OCDD)及其剂量对吸收的影响 正在老鼠身上进行研究。

Halogenated dibenzofurans are found worldwide as environmental pollutants. Structurally related to other halogenated aromatic xenobiotics, their toxicity and disposition seem to vary with the degree and position of halogenation. This work has established that 2,3,7,8-tetrachlorodibenzofuran (TCDF), an extremely toxic isomer, is excreted only after metabolism and toxicity is inversely related to metabolic capability. The metabolites of TCDF produced by the rat are being characterized. There appear to be threshold body burden for toxicity. The distribution to the fetus was examined after maternal exposure. The role of body composition on the disposition of 2,3,7,8-tetrachlorodibenzodioxin (TCDD), the most toxic man-made compound known, is being examined in congenic mouse strains which are sensitive or resistant to TCDD toxicity. Absorption of octachlorodibenzo-p-dioxin (OCDD) from the gastrointestinal tract and the effect of dose on absorption is being studied in the rat.