CHEMICALLY-INDUCED AND SPONTANEOUS MONONUCLEAR CELL LEUKEMIA IN FISCHER 344 RATS

NTP慢性毒性试验结果表明， 单核细胞白血病（MNCL）。 它 很难确定MNCL的化学诱导是否发生在 慢性试验，因为自发性MNCL的发生率很高。 响应 包括统计上显著增加或 下降，以及积极或消极的趋势， 次给药结束 MNCL的移植模型的特征在于其 临床表现、大体病理学、细胞形态学和生物化学， 组织病理学和临床血液学和化学。 皮下 将2 x 10E7活白血病细胞接种到大鼠中，临床症状， MNCl导致的发病率和死亡率在100天（95至105天）后发生。 临床症状通常在90天后出现。 不过有了这 开始出现肿块、脾肿大和白细胞计数增加 65天后。 1985财政年度，该研究项目的目标是开发 评估化学处理对环境影响的短期试验模型 F344雄性大鼠移植性单核细胞白血病的表达。

NTP chronic toxicity test results indicate a high incidence of rat mononuclear cell leukemia (MNCL) in both control and treated F344 rats. It is difficult to determne if chemical induction of MNCL has occurred in a chronic test because of the high incidence of spontneous MNCL. Responses to chemical treatment have included statistically significant increases or decreses in MNCL as well as positive or negative trends with respect to dose. A transplant model for MNCL has been characterized in terms of its clinical presentation, gross pathology, cell morpholgy and biochemistry, histopathology, and clinical hematology and chemistry. After subcutaneous inoculation of 2 x 10E7 viable leukemic cells into rats, clinical symptoms, morbidity and mortality due to MNCl occur after 100 days (95 to 105 days). Clinical symptoms are usually present after 90 days. However, with this size incoclum, splenomegaly and leukocyte count increase start to occur after 65 days. The FY 1985 objective of this reserch project is to develop a short-term test model for assessing the effect of chemical treatmet on the expression of transplanted mononuclear cell leukemia in F344 male rats.