A Network for Studying Psychological Resilience in Low and Middle-Income Countries (NESP)

对最常见的精神健康障碍（抑郁、焦虑、药物和酒精滥用）的脆弱性或复原力与遗传易感性、早期生活因素和个人当前环境的综合有关。95%以上的研究仅限于高收入国家，这些研究证实了基因、发育和成人环境的重要性。然而，在低收入和中等收入国家，人们对这些因素知之甚少，在这些国家，这种常见精神健康障碍的负担甚至比高收入国家更为沉重。在这里，我们建议建立一个强大的全球领导人网络，以分析世界上三个地区（尼泊尔、马拉维和哥斯达黎加）三个不同的中低收入国家环境中的关键因素。这将使我们能够系统地确定导致对常见精神健康障碍的脆弱性或复原力的过程，并利用这种知识，在全球领先的数据科学和国内专业知识的支持下，制定具体办法，加强复原力并支持预防、诊断和治疗。我们的方法是高度多学科的，结合遗传学，临床和社会科学专业知识，提供个人遗传学，发育和环境的全面观点。我们将把这些专业知识与世界领先的信息学能力结合起来，创建一个网络，用于研究不同环境和经济体的心理弹性。

Vulnerability to or resilience to the commonest mental health disorders (depression, anxiety, drug and alcohol misuse) is related to the combination of genetic susceptibility, early life factors and an individual's current environment. Studies, over 95% of which have been confined to high income countries (HICs), have confirmed the importance of genes, development and adult environment. However, very little is known of these factors in low and middle-income countries (LMICs), where the burden of such common mental health disorders is even more substantial than in HICs.Here we propose a powerful network of global leaders to analyse the key factors in three contrasting LMIC settings in three regions of the world, Nepal, Malawi and Costa Rica. This will enable us systematically to determine the processes leading to vulnerability or resilience to common disorders of mental health and exploit this knowledge, enabled by globally-leading data sciences and within-country expertise, to develop specific approaches to reinforce resilience and support prevention, diagnosis and treatment.Our approach is highly multidisciplinary, combining genetic, clinical and social sciences expertise to provide a comprehensive view of an individual's genetics, development and environment. We will combine this expertise with world-leading informatics capacity to create a network for the study of psychological resilience across diverse environments and economies.