Understanding Signalling Pathways Mutated in Inherited Disorders

我的实验室致力于解开一类重要的酶所扮演的角色，这些酶与人类疾病有关，控制着一种被称为“蛋白质磷酸化”的生物过程。许多疾病，包括帕金森病，癌症和高血压，都是由调节蛋白磷酸化的特定途径的改变引起的。我的研究计划将基于破译与帕金森病（LRRK2），癌症（SGK3途径）和高血压（WNK途径）相关的蛋白质磷酸化途径的分子细节。我们研究的首要目标是发现调节磷酸化的酶的破坏如何与人类疾病联系在一起。我们的目标是利用这些信息，并与临床医生以及制药公司合作，制定更好的策略，以更好地治疗和诊断疾病。

My laboratory focuses on unravelling the roles played by an important class of enzymes that are implicated in human disease, that control a biological process known as “protein phosphorylation”. Many diseases including Parkinson’s disease, cancer and high blood pressure, are caused by alterations in specific pathways that regulate protein phosphorylation. My research programme will be based on deciphering the molecular details of protein phosphorylation pathways that are associated with Parkinson’s Disease (LRRK2), cancer (SGK3 pathway) and hypertension (WNK pathway). The overarching goal of our research is to discover how disruptions in enzymes that regulate phosphorylation are linked to human disease. We aim to harness this information and work with clinicians as well as pharmaceutical companies to develop improved strategies to better treat and diagnose malady.