A transdiagnostic, translational approach to the understanding, prevention and treatment of mood, anxiety and stress disorders across the lifespan

常见的心理健康问题，如情绪、焦虑和与压力相关的障碍，在我们的一生中影响着一半以上的人，最初通常发生在童年或青春期。它们是导致残疾、卫生服务使用、经济成本和痛苦的全球主要原因。即使是我们目前最好的治疗这些疾病的方法，也会让大约一半的患者持续感到痛苦，而且问题通常会在以后再次出现。因此，改善这些疾病的治疗和预防是当务之急。这个项目利用我们所说的‘基础科学’，通过不同的方法，从大脑成像到心理学实验，进一步了解这些疾病的性质。然后，我们使用这些基本发现来发展和改进我们对这些障碍的心理治疗，包括儿童、青少年和成人。然后在我们所称的随机对照试验中对这些治疗方法进行评估，即将新的/改进的治疗方法与我们已经知道有效的现有治疗方法进行比较，看看新的治疗方法是一样好还是更好。

Common mental health problems such as mood, anxiety and stress-related disorders are impact more than half of us during our lifetimes, and initially occur typically during childhood or adolescence. They are a leading worldwide cause of disability, health-service use, economic cost, and suffering. Even the best of our current treatments for these disorders leave around half of patients with ongoing disabling levels of distress, and problems commonly return later. Improving the treatment and prevention of these conditions is therefore a priority. This programme uses what we call ‘basic science’ to further understand the nature of these disorders using different methods from brain imaging through to psychological experiments. We then use these basic findings to develop and improve our psychological treatments for these disorders, for children adolescents and adults. These treatments are then evaluated within what we call randomised controlled trials, where the new/improved treatment is compared against an existing treatment which we already know works, to see if the new treatment is as good or better.