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The dynamic interactive neurocognitive systems underpinning language and semantic cognition, and their disorders.

The dynamic interactive neurocognitive systems underpinning language and semantic cognition, and their disorders.
支持语言和语义认知的动态交互式神经认知系统及其疾病。
批准号:
MC_UU_00030/9
负责人:
Matthew Lambon Ralph
金额:
$350.79万
依托单位:
依托单位国家:
英国
项目类别:
Intramural
财政年份:
2022
资助国家:
英国
项目状态:
未结题
起止时间:
2022 至 --

项目摘要

项目成果

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中文摘要
翻译
语言是一种基本能力,它几乎是我们个人、社会和职业生活各个方面的核心。因此,当语言受到损害时,人们可能会有严重的残疾。语言障碍在多种急性和慢性脑损伤中很常见,包括中风、多种类型和亚型的痴呆、急性神经系统疾病等。因此,我们长期神经科学研究项目的核心目标是(i)了解支持健康语言功能的过程、计算和大脑机制;(二)调查不同类型脑部疾病的语言障碍的性质;(iii)探索这些过程在脑损伤后是如何部分恢复的,为什么这种恢复因人而异,以及语言康复的基础。我们的研究计划将使用各种方法和技术来探索健康人和患者的功能。这些方法包括脑成像、脑刺激、基于计算机的模型和先进的数学分析技术。我们在一些新工作中的目标是了解大脑如何在正常操作中保持灵活和高效,它如何对脑损伤做出反应,反过来,如何最大限度地提高患者的康复。
英文摘要
Language is a fundamental ability that is core to almost every aspect of our personal, social and professional lives. Consequently, when language is compromised, people can have severe disabilities. Language impairments are common across multiple types of acute and chronic brain damage including stroke, multiple types and subtypes of dementia, acute neurological diseases, etc. The core goals of our long-term neuroscience research programme, therefore, are to (i) understand the processes, computations and brain mechanisms that support healthy language function; (ii) investigate the nature of language disorders across different types of brain disease; and (iii) explore how these process partially recovery after brain damage, why this recovery varies across people and the bases of language rehabilitation. Our research programme will use a variety of methods and techniques to explore function in healthy people and in patients. These methods include brain imaging, brain stimulation, computer based models and advanced mathematical analysis techniques. Our target in some of the new work is to understand how the mind can be flexible and efficient in normal operation, how it responds to brain damage and, in turn, how to maximise patients’ recovery.
期刊论文(10)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1080/02687038.2021.1923946
发表时间: 2022-08-03
期刊: Aphasiology
影响因子: 2
作者: [Alyahya RSW, Conroy P, Halai AD, Ralph MAL]
通讯作者: Ralph MAL
DOI: 10.1093/cercor/bhac358
发表时间: 2023-04-04
期刊: Cerebral cortex (New York, N.Y. : 1991)
影响因子: --
作者: []
通讯作者:
DOI: 10.1093/braincomms/fcac147
发表时间: 2022
期刊: Brain communications
影响因子: 4.8
作者: []
通讯作者:
The neurocognitive cornerstones of creative thought
创造性思维的神经认知基石
DOI: 10.31234/osf.io/mv2q7
发表时间: 2023
期刊:
影响因子: --
作者: [Chan M]
通讯作者: Chan M
共 8 条
    Perturbing physiological systems: Measuring the stimulated the brain
    • 批准号:
      MC_PC_20046
    • 项目类别:
      Intramural
    • 资助金额:
      $22.55万
    • 财政年份:
      2021
    • 负责人:
      Matthew Lambon Ralph
    • 依托单位:
    The flexible and interactive neural, computational and neurobiological mechanisms underpinning semantic cognition and its disorders.
    • 批准号:
      MR/R023883/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $191.62万
    • 财政年份:
      2018
    • 负责人:
      Matthew Lambon Ralph
    • 依托单位:
    UKDP: Integrated DEmentiA research environment (IDEA)
    • 批准号:
      MR/M024997/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $776.12万
    • 财政年份:
      2015
    • 负责人:
      Matthew Lambon Ralph
    • 依托单位:
    Towards a unified, computationally-implemented neural network for understanding semantic cognition and its disorders.
    • 批准号:
      MR/J004146/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $214.35万
    • 财政年份:
      2012
    • 负责人:
      Matthew Lambon Ralph
    • 依托单位:
    海外基金