CHARACTERIZATION OF IMMUNE RESPONSES TO RETINAL SPECIFIC ANTIGENS

S抗原（S-Ag）和感光细胞间的特征之一 类维生素A结合蛋白（IRBP），其为视网膜特异性抗原， 当在佐剂存在下注射时， 在实验动物的眼睛中诱导强烈的自身免疫性炎症， 动物这种疾病称为实验性自身免疫性葡萄膜炎（EAU）， 严重依赖于T细胞和抗原处理， 抗原呈递细胞（APC）。处理外源性的第一步 抗原是它们通过胞饮内化到APC中，或 吞噬作用抗原的加工或分解发生在 酸性内吞囊泡，导致产生小的 多肽。一旦产生，这些小多肽必须 防止进一步降解并运输到后高尔基体 复合物，在那里它们可以与II类抗原结合。有人认为 热休克蛋白（hsp）可能在这两个过程中发挥重要作用， 流程.

One of the characteristics of S-Antigen (S-Ag) and interphotoreceptor retinoid-binding protein (IRBP), which are retinal-specific antigens, is their ability, when injected in the presence of an adjuvant, to induce an intense autoimmune inflammation in the eyes of experimental animals. This disease, called experimental autoimmune uveitis (EAU), is critically dependent on T cells and antigen processing by antigen-presenting cells (APC). The first step in processing exogenous antigens is their internalization into an APC by pinocytosis or phagocytosis. Processing or breakdown of the antigen occurs within acidic endocytic vesicles, resulting in the generation of small polypeptides. Once generated, these small polypeptides must be protected from further degradation and transported to the post-Golgi complex, where they can associate with class II antigens. It is felt that heat shock proteins (hsp) may play an important role in both processes.