ASTHMA AND STRESS

人们普遍认为，有压力的生活事件会让人 易患哮喘的易患哮喘的我们提出了一个主题内的设计 在那里，志愿者接受一次支气管收缩挑战 在相对紧张的条件下，一旦在相对平静的情况下 条件下，一次是在空档期间。这项挑战将涉及 确定效应的剂量-反应曲线， FEV1测定支气管缩窄器对肺功能的影响。志愿者将 被随机分配到条件秩序(压力，然后冷静或冷静 压力)。我们将使用甲氧胆碱作为支气管束缩窄剂。

It is commonly believed that stressful life events make people more susceptible to asthmatic events. We propose a within subject design where volunteers are administered a bronchoconstrictor challenge once under relatively stressful conditions, once under relatively calm conditions, and once during a neutral period. The challenge will involve determining a dose-response curve for the effects, of the bronchoconstrictor on lung function as measured by FEV1. Volunteers will be randomly assigned to condition order (stress then calm or calm then stress). We will use methacoline as the bronchoconstrictor.