Abubakar;Pwani;Adolescent Executive Functioning Association with Scholastic Outcomes, Risk Taking Behavior and Medical Adherence in the Context of HIV

由于抗逆转录病毒(ARV)的提供，艾滋病毒阳性的儿童寿命更长。然而，为了充分发挥他们的潜力，这些儿童需要接受干预措施，以减少艾滋病毒的负面影响。在非洲，指导制定这些亟需的干预计划的研究证据有限。我建议研究艾滋病毒暴露对肯尼亚海岸10-14岁青少年功能的影响。共招募552名10-14岁青少年(HIV感染者184人，HIV暴露者未感染者184人，未暴露者184人)。将采用纵向研究设计。每个科目将在24个月内进行三次评估，每次评估之间相隔12个月。我们将使用直接的心理评估，辅以父母的报告，并将对数据进行统计分析，以确定艾滋病毒相关损害的性质和先兆。确定不良神经心理结果的来源将提供有用的干预点信息。

Children born HIV positive are living longer due to the availability of Antiretroviral (ARVs). However, to realize their full potential these children need to receive interventions that reduce the negative impact of HIV. In Africa, there is limited research evidence to guide the development of these much needed intervention programmes. I propose to study the impact of HIV exposure on the functioning of adolescents aged 10-14 years at the Kenyan Coast. A total of 552 (184 HIV infected, 184 HIV exposed uninfected and 184 unexposed randomly selected from the community) adolescents aged 10-14 years shall be recruited. A longitudinal study design will be used. Each subject will be assessed thrice, within a 24 months period with 12 months between each assessment. We will use direct psychological assessment complemented by parental report and will statistically analyse the data to identify the nature and antecedents of HIV-related impairments. Identifying sources of poor neuropsychological outcomes will provide information on useful points of intervention.