MOVEMENT ORGANIZATION DYSFUNCTION IN PARKINSONS

虽然近年来帕金森病的研究取得了进展，但该病的发病机制仍不清楚。该项目的主要目标是量化帕金森病患者复杂的多关节运动受损程度，从而更好地了解运动控制原则如何受损。 我们关于帕金森病患者的工作假设是，他们在复杂运动中的困难主要来自于他们无法协调身体部位。 我们使用一个躯干辅助的扩展任务和分析躯干，手臂，和光圈同步时，速度，准确性，序列的部分，和视觉反馈的限制。 我们将分析身体部分同步，相对定时，空间不变性，和协同作用。 总的来说，这些实验的结果将使我们能够更好地了解PD如何影响复杂动作执行过程中的运动协调模式。 帕金森病患者的“关闭”与“打开”状态的比较可能有助于确定协调障碍是否具有共同的左旋多巴基础。 提出的实验是系统的，新颖的，并使用经过验证的方法。 拟议的研究应促进理解的基本原则，指导协调的多关节运动在正常的科目。 它还将增加对帕金森病患者在使用这些原则时受到限制的方式的理解。 四个实验的结果应该对基础神经科学家和临床科学界都有用，减少神经机制基础知识和治疗干预之间的差距。

While advances in Parkinson's disease have been established in recent years, the pathogenesis of the disease is still not well understood. The primary goal of this project is to quantify how complex multijoint movement is impaired in Parkinsonian patients, thereby providing a better understanding of how motor control principles are compromised. Our working hypothesis concerning PD patients is that much of their difficulty with complex movements arises from their inability to coordinate body segments. We use a trunk-assisted prehension task and analyze trunk, arm, and aperture synchronization when speed, accuracy, sequencing of segments, and visual feedback constraints are imposed. We will analyze body segment synchronization, relative timing, spatial invariance, and synergies. Collectively, the results from these experiments will allow us to better understand how PD affects movement coordination patterns during the performance of complex actions. Comparisons of 'off' vs. 'on' states in Parkinson's disease patients may help determine if coordination impairments share a common levodopa basis. The experiments proposed are systematic, novel and use proven methodology. The proposed research should advance understanding of the fundamental principles that guide the coordination of multijoint movements in normal subjects. It will also increase understanding of the ways in which Parkinson's disease patients are restricted in the use of these principles. The results from four experiments should be useful to both the basic neuroscientist and clinical science communities, reducing the gap between fundamental knowledge of neural mechanisms and therapeutic intervention.