ANIMAL MODEL FOR DIURNAL CIRCADIAN RHYTHMS--O DEGUS

描述（改编自申请人的摘要）：各种环境 生活的变化改变了人类的昼夜节律， 导致生理和心理问题。 夹带量变化 昼夜节律，由于性别和生理时钟类型，以及节奏问题 中断可能是敏感性差异的结果， 对娱乐性光和非光环境线索的响应， 例如光暗循环和社会互动。 已经研究了昼夜节律系统被光/暗周期的夹带 尤其是在夜间活动的啮齿类动物中。 与此相反， 已经确定了许多非光刺激， 自由运行的昼夜节律，但我们只有一个有限的想法，这些 刺激到达昼夜节律系统，因为大多数非光刺激是 复杂并使用多个感觉系统。 更好地了解如何 与昼夜节律系统相互作用的非光刺激将得到最好的发展 只有一个感觉系统参与的时间表 Eddon degus是探索 昼夜节律系统的非光干扰物和 这些互动的神经基础。 德古斯是一个高度社会化的， 白天活动的啮齿动物，表现出与人类相似的节律， 被光线和社会互动所吸引。 这一建议所要检验的假设集中在社会互动如何 degus能够控制昼夜节律。 目标1. 确定是否 传递到主嗅觉系统的嗅觉线索足以 控制昼夜节律系统 实验将检验空气中的气味 暗示可以取代社会互动， 跟随相移并将动物带入恒定条件下， 进步和拖延。 目标2：界定联合国系统的关键组成部分， 将气味线索传递给昼夜节律系统的神经回路。 实验将使用束跟踪，选择性损伤和Fos 免疫组化以确定参与的功能性神经解剖学， 通过嗅觉/社会刺激来娱乐昼夜节律。 成功完成拟议的研究将产生第一个 详细的行为/神经解剖模型的相互作用，非光的 时间表和生物钟。 与degus的合作最终 使研究人员能够分析光与光之间的相互作用， 在昼夜节律的控制中的非光夹带线索， 社会性哺乳动物，有许多与人类相似的特性，并可能导致 对昼夜节律紊乱的非光治疗。

DESCRIPTION (adapted from applicant's abstract): A variety of environmental and life changes alter human circadian rhythms, and in some individuals cause physiological and psychological problems. Variation in entrained circadian rhythms, due to sex and chronotype, and problems of rhythm disruptions are likely the result of differences in sensitivity or responsiveness to entertaining photic and non-photic environmental cues, such as the light/dark cycle and social interactions. Entrainment of the circadian system by the light/dark cycle has been studied at many levels of analysis particularly in nocturnal rodents. In contrast, a number of non-photic stimuli have been identified that alter entrained or free-running circadian rhythms, but we have only a limited idea of how these stimuli reach the circadian system because most non-photic stimuli are complex and employ multiple sensory systems. A better understanding of how non-photic stimuli interact with the circadian system will best be developed with a zeitgeber that engages only one sensory system. Octodon degus serve as an ideal model for exploration of the interaction of non-photic entrainers of the circadian system and determination of the neural underpinnings of those interactions. Degus are a highly social, diurnal rodents, displaying rhythms similar to those of humans , which are entrained by light and social interactions. Hypotheses to be tested by this proposal focus on how social interactions of degus are able to entrain circadian rhythms. Aim 1. Determine whether olfactory cues delivered to the main olfactory system are sufficient to entrain circadian system. Experiments will examine whether airborne odor cues can replace social interactions for accelerated re-entrainment following phase shifts and entrain animals in constant conditions by phase advances and delays. Aim 2: Delineate the critical components of the neural circuitry transmitting odor cues to the circadian system. Experiments will use tract tracing, selective lesions and Fos immunohistochemistry to determine the functional neuroanatomy involved in the entertainment of circadian rhythms by olfactory/social stimuli. Successful completion of the proposed research will produce the first detailed behavioral/neuroanatomical model of the interaction of non-photic zeitgeber and the circadian clock. This work with degus will eventually allow the investigators to analyze the interactions between photic and non-photic entraining cues in the control of circadian rhythms in a diurnal, social mammal with many properties similar to humans, and may lead to non-photic treatments for circadian disruptions.