NOVEL BIOMIMETIC COATING FOR CIRCULATORY DEVICES

外来物质的致血栓性是限制循环支持装置和与血液直接接触的其它装置的长期使用的主要问题之一。大量研究表明，表面改性可显著降低异物表面的血栓形成特性。一种非常有前途的新技术是由Marchant等人开发的仿生表面活性剂聚合物涂层。该涂层在石墨基底上但在低剪切应力环境下显示出优异的非血栓形成性能。在第一阶段，我们将评估这种新型涂层用于体外血泵的可行性，目前BIOMEC正在设计这种新型涂层。我们将在泵的关键表面涂覆表面活性剂聚合物涂层，这些表面已经涂覆有类金刚石膜。为了评价我们的涂层在血泵高剪切应力条件下的稳定性，我们将在旋转圆盘装置中使测试样品经受高剪切应力。如果成功，这将证明表面活性剂聚合物涂层用于血泵和其他循环装置（如心脏瓣膜、膜式氧合器插管和心室辅助装置）的可行性，并将改善移植和其他心脏手术的结果。拟议的商业应用：本提案拟开发的仿生涂层适用于具有血液接触表面的器械，包括血泵、心室辅助器械、人工心脏瓣膜和体外膜式氧合器套管。

Thrombogenicity of foreign substances is one of the leading issues limiting long term use of circulatory support devices and other devices having direct contact with blood. Numerous studies indicate that thrombogenic properties of a foreign surface can be significantly reduced by surface modifications. One very promising new technology is a biomimetic surfactant polymer coating developed by Marchant et. al. This coating has demonstrated excellent non-thrombogenic properties on graphite substrates, but under low shear stress environments. In Phase I, we will evaluate the feasibility of this novel coating for use in an extracorporeal blood pump, which is currently under design at BIOMEC. We will apply the surfactant polymer coating to critical surfaces of the pump, which have been coated with diamondlike carbon film. To evaluate the stability of our coating under the high shear stress conditions of the blood pump, we will subject test samples to high shear stress in a rotating disk apparatus. If successful, this will demonstrate the feasibility of surfactant polymer coatings for blood pumps and other circulatory devices, such as heart valves, cannulas for membrane oxygenators, and ventricular assist devices, and will improve the outcome of transplantations and other cardiac procedures. PROPOSED COMMERCIAL APPLICATIONS: The biomimetic coatings to be developed in this proposal are applicable to devices with blood contacting surfaces, including blood pumps, ventricular assist devices, artificial heart valves, and cannulas for extracorporeal membrane oxygenators.