ANTIPLATELET NITRIC OXIDE-RELEASING POLYMER COATINGS

描述：（改编自申请人的摘要）。一氧化氮（NO）供体 化合物已显示有效降低血小板粘附于 聚合物表面。直到最近，供体化合物与聚合物混合 并用作涂层，NO在血液/塑料界面处释放。 NO释放反应的不希望的副产物的浸出导致 努力将NO供体直接共价键合到聚合物主链上。 使用这种NO释放聚合物的初步研究已经显示出显著的 成功 在这项研究的第二阶段，几种常见的聚合物将被改性， 添加NO供体基团，使用经证实的合成技术。所得 聚合物将被挤压成管，这将在体外进行测试，并在一个 体外循环体内模型， 材料的化学和生物相容性。制造业， 将研究这些NO释放聚合物的加工和储存。的 本研究的目的是确定一种实用有效的方法， 在血液接触的制造或涂层中使用NO释放聚合物 装置. 拟定商业应用： 本项目开发的一氧化氮释放聚合物具有潜在的商业价值 在改善血液接触表面的生物相容性方面的应用。 例子包括 制造和/或涂覆用于心/肺机械的管路和血液接触器械 和血液透析。 这些化合物也可用于植入装置或用于局部化治疗。 一氧化氮释放

DESCRIPTION: (Adapted from the applicant's abstract). Nitric Oxide (NO) donor compounds have been shown to be effective in decreasing platelet adhesion to polymer surfaces. Until recently, the donor compounds were mixed with polymers and used as a coating, and NO was released at the blood/plastic interface. Leaching of undesirable by-products of the NO release reaction resulted in efforts to covalently bond NO donors directly to the polymer backbone. Preliminary studies with such NO releasing polymers have shown remarkable success. In Phase II of this research, several common polymers will be modified by the addition of NO donor groups, using proven synthesis techniques. The resulting polymers will be extruded into tubing, which will be tested in vitro and in an in vivo model of extracorporeal circulation to investigate mechanical, chemical, and biocompatibility properties of the materials. Manufacturing, processing, and storage of these NO release polymers will be investigated. The aim of this research is to determine a practical and effective means of employing NO releasing polymers in fabrication or coating of blood contact devices. PROPOSED COMMERCIAL APPLICATION: The nitric oxide-releasing polymers developed in this project will have potential commercial applications in improving biocompatibility of blood-contract surfaces. Examples include the manufacture and/or coating of tubing and blood contact devices used in heart/lung mechanes and hemodialysis. These compounds may also be used in implanted devices or for localized nitric oxide delivery.