BASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASES

这是一个新申请的培训计划，每年支持6名博士后培训生（医学博士和/或博士）和6名博士生（医学博士/博士），重点是细胞和分子生物学/基因治疗免疫学。博士后平均培养时间为3年，博士生平均培养时间为4年。13个成熟的导师将在高度活跃和互动的研究实验室提供广泛的培训，从事各种人类疾病的细胞、分子生物学和免疫学基本方面的最新研究，并为其中一些疾病开发新的基因治疗方法的前景。大多数教师都住在微生物和免疫学系新建或翻修的宽敞实验室里；医学部血液肿瘤科；药物与分子遗传学；Herman B Wells儿科研究中心，儿科学系；以及瓦尔特肿瘤中心，位于三座相邻的建筑中。每位导师在同行评审出版物和校外资助方面的良好记录是拟议培训方案的主要优势。由于各种导师之间积极、持续的科学合作，追求多学科研究的机会很多。一个重要的重点放在促进和培养下一代生物医学研究人员的发展，他们致力于学术医学的科学事业，成为独立的研究人员，反过来，他们自己也将富有成效和竞争力。对工作人员和访问科学家采取多管齐下的办法；正式和非正式的课程和讨论会；实验室会议;参加国家、国家和国际科学会议已经到位，并将进一步强调。与实验室合作的决定将由受训者和导师共同同意，而由具有多学科研究兴趣的导师组成的研究委员会将促进受训者的科学发展。可用的主要资源包括国际公认的临床和基础科学研究项目，美国仅有的三个nih指定的国家基因载体实验室之一，最先进的基础设施，以及与布卢明顿印第安纳大学、西拉菲特普渡大学的活跃研究人员的频繁联系，所有这些都近在咫尺，以及国内和国际上的其他研究人员。

This is a new application for a training program to support 6 postdoctoral trainees (M.D. and/or Ph.D.) and 6 predoctoral students (M.D./Ph.D.) per year with a strong emphasis on cell and molecular biology/immunology of gene therapy. The average training period for postdoctoral and predoctoral students will be 3 years and 4 years, respectively. Thirteen well-established preceptors will provide extensive training in highly active as well as interactive research laboratories pursuing state of the art research on fundamental aspects of cellular, molecular biological, and immunological aspects of a variety of human diseases, and the prospects of developing noel gene therapy approaches for some of these disorders. Most of the preceptors are housed in newly built or renovated spacious laboratories in the Department of Microbiology and Immunology; Division of Hematology/Oncology, Department of Medicine; Department of Medicinal and Molecular Genetics; Herman B Wells Center for Pediatric Research, Department of Pediatrics; and the Walther Oncology Center, in three adjoining buildings. Strong track-records of peer-reviewed publications and extramural funding of each of the preceptors a major strength of the proposed training program. Ample opportunities for pursuing multi- disciplinary research exist due to active, ongoing scientific collaborations among various preceptors. A significant emphasis is placed to promote and foster the development of the next generation of biomedical researchers committed to scientific careers in academic medicine to become independent investigators who, in turn, will themselves be productive and competitive. A multi-pronged approach for staff members and visiting scientists; formal and informal courses and seminars; laboratory meetings; and participation in state, national and international scientific meetings, is already in place and will be further emphasized. The decision to associate with a laboratory will be made by mutual consent of the trainee and the preceptor, and the scientific development of the trainee will be facilitated by a research committee composed of preceptors with multi-disciplinary research interests. Major resources that are available include internationally recognized clinical and basic science research programs, one of only three NIH-designated National Gene Vector Laboratories in the U.S., state of the art infrastructure, and frequent contacts with active investigators at Indiana University in Bloomington, Purdue University in West Lafayette, all in close proximity, and other investigators nationally as well as internationally.