OHSU HUMAN INVESTIGATIONS PROGRAM

在过去的二十年里，分子和细胞生物学、信息学和临床试验方面的许多进步对当前和未来的临床研究者掌握一套新的研究技能提出了额外的要求。不幸的是。当临床研究人员成功职业所需的必要技能变得更加广泛时，来自医师临床研究人员的NIH拨款申请数量一直在减少。在美国，以患者为导向的研究很可能会继续受到影响，除非我们认真努力，旨在增加计划从事人体研究的临床研究人员的数量和能力水平。该奖项概述的培训计划是对加强技能建设和增加临床研究人员数量的需求的及时和具体的回应。俄勒冈健康科学大学（OHSU）装备精良，可以为临床研究人员提供全面的培训，教授必要的研究技能，并为人体研究提供广泛的基础。OHSU人类调查计划的具体目标源于所有临床研究者都必须具备核心技能的假设；这些技能是可以教的；不同背景的调查人员的技能是相似的；研究技能的重点应该基于将基础科学理念转化为临床的需要。这一应用的目的包括：在西北地区增加成功的、全面训练的临床研究者的数量；通过为临床研究员和初级教员提供正式课程，扩大和丰富OHSU目前在人体调查方面的培训活动；提供有指导的培训内容，以进一步促进学习者的发展；创建一个基于网络的学习计划，允许受临床时间表或地理限制的学习者参与。我们的活动将利用基于问题的学习技术和正式的教学课程，这些课程将根据临床研究者学员的需要量身定制。我们的努力将有助于国家运动，以增加临床研究者池的规模，以及对人类研究为基础的职业感兴趣的年轻临床研究人员的能力水平。

The many advances in molecular and cell biology, in informatics, and in Clinical trials over the past twenty years have placed additional demands for mastery of a new set of research skills for current and future clinical investigators. Unfortunately. at the time when the necessary skills for successful careers for clinical investigators have become broader, the numbers of NIH grant applications from physician clinical investigators has been decreasing. Patient oriented research in the U.S. is likely t6 continue to suffer unless serious efforts are aimed at increasing the number and the level of competency of clinician investigators who plan careers in human investigation. The training program outlined in this award is a timely and specific response to the need to enhance skill building and to increase the number of clinical investigators. Oregon Health Sciences University (OHSU) is well equipped to provide comprehensive training to clinical investigators, to teach necessary research skills, and to offer a broad foundation in human investigations. The specific aims of the OHSU Human Investigations Program derive from the hypotheses that a core skill set is necessary for all clinical investigators; that this skill set can be taught; that the skills are similar for investigators from a variety of backgrounds; and that the focus of the research skill set should be based on the need to translate basic science ideas to the bedside. The aims of this application include: increasing the number of successful, comprehensively trained clinical investigators in the Northwest; augmenting and enriching the current training activities in human investigations at OHSU by offering a formal curriculum for clinical fellows and Junior faculty; providing a mentored training component to further learner development; and, creating a Web-based learning program that will allow participation of learners who are limited by clinical schedules or by geographic constraints. Our activities will make use of problem-based learning techniques and formal didactic sessions that will be well-tailored to the needs of the clinical investigator trainees. Our efforts will assist the national movement to increase the size of the clinical investigator pool, as well as the level of competency of young clinical researchers who are interested in human investigations-based careers.