FIBROMYALGIA--CENTRAL FACTORS IN ITS ETIOPATHOGENESIS

本研究的主要目的是检查3组受试者的疼痛敏感性、脑脊液（CSF）中P物质水平和脑局部脑血流量（rCBF）的实验室指标。 这些组是（a）患有纤维肌痛的风湿病诊所患者;（B）患有纤维肌痛的社区居民，他们没有咨询医生关于他们的疼痛症状;和（c）健康对照。 我们的大多数发现与我们的假设一致。 也就是说，纤维肌痛患者和社区居民在疼痛敏感性、CSF P物质水平和静息状态下脑rCBF水平方面与健康对照组不同。 此外，有纤维肌痛患者和社区居民在这些变量上的差异不大，尽管事实上，患者表现出显着更高水平的心理困扰。因此，纤维肌痛患者和健康人之间疼痛敏感性和疼痛相关生理变量的差异主要不是由于心理困扰。

The major aim of this study is to examine laboratory measures of pain sensitivity, cerebral spinal fluid (CSF) levels of substance P, and brain regional cerebral blood flow (rCBF) in 3 groups of subjects. These groups are (a) rheumatology clinic patients with fibromyalgia; (b) community residents with fibromyalgia who have not consulted a physician about their painful symptoms; and (c) healthy controls. Most of our findings have been consistent with our hypotheses. That is, both the patients and community residents with fibromyalgia differ from health controls in pain sensitivity, CSF levels of substance P, and in resting state levels of brain rCBF. Moreover, there are few differences between patients and community residents with fibromyalgia on these variables despite the fact that patients show significantly higher levels of psychological distress. Thus, differences in pain sensitivity and pain-related physiologic variables between persons with fibromyalgia and healthy individuals are not due primarily to psychological distress.