CORE--SOLID TUMOR PHARMACOLOGY

实体瘤药理学核心的职能是： A. 进行药物和药物代谢物定量分析 从动物身上采集的生物样本中的浓度， 作为临床前和临床药代动力学研究一部分的患者 在这个方案中。 B。 根据需要执行额外的特殊实验室程序， 支持本计划中的项目。 C. 进行适当的生化分析（例如，免疫印迹分析 对于拓扑异构酶I，拓扑异构酶I）对 临床前和临床样品，以评价抗癌活性 药物，以提供更全面的药效学分析。 D. 维护计算机数据库中的分析数据， 实体瘤药理学核心，并生成数据检索和报告 按要求 E. 分析从临床前和临床中获得的药代动力学数据 药代动力学研究，并适合适当的药代动力学和 根据研究者的要求， 这个戒酒会这

The functions of the Solid Tumor Pharmacology Core are to: A. Perform assays to quantitate drug and drug metabolite concentrations in biological specimens collected from animals and patients as part of preclinical and clinical pharmacokinetic studies within this Program. B. Perform additional special laboratory procedures as required to support the projects included in this Program. C. Perform appropriate biochemical assays (e.g., immunoblot analysis for topoisomerase I, catalytic activity of topoisomerase I) on preclinical and clinical samples to evaluate the activity of anticancer drugs to provide more comprehensive pharmacodynamic analyses. D. Maintain computer databases of data from analyses performed in the Solid Tumor Pharmacology Core, and generate data retrievals and reports as required. E. Analyze pharmacokinetic data obtained from preclinical and clinical pharmacokinetic studies, and fit appropriate pharmacokinetic and pharmacodynamic models to the data, as requested by investigators in this Program.