Development of Flightless antibody therapy for treating wounds
Development of Flightless antibody therapy for treating wounds
批准号:
nhmrc : 508006
负责人:
Prof Allison Cowin
金额:
$12.94万
依托单位国家:
澳大利亚
项目类别:
NHMRC Development Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
慢性伤口、糖尿病溃疡、创伤、烧伤和烫伤引起的伤害形成了医疗需求,随着人口老龄化和糖尿病流行病的增长,这种需求只会扩大。在我们的研究中,我们已经表明,Flightless I(FliI),一种肌动蛋白重塑蛋白,是切口伤口愈合的负调节因子。我们现在正在开发一种新的抗体疗法,以降低伤口中的FliI水平,从而改善伤口修复结果。
英文摘要
Chronic wounds, diabetic ulcers, injuries in response to trauma, burns and scalds form a medical need which will only expand as the population ages and the diabetic epidemic grows. In our studies, we have shown that Flightless I (FliI), an actin-remodelling protein, is a negative regulator of incisional wound healing. We are now developing a new antibody therapy to reduce FliI levels in wounds thereby leading to improved wound repair outcomes.
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会议论文
Modulating sphingolipid signalling to enhance wound healing
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批准号:nhmrc : GNT1124961
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项目类别:Project Grants
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资助金额:$69.84万
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财政年份:2017
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负责人:Prof Allison Cowin
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依托单位:
Modulating sphingolipid signalling to enhance wound healing
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依托单位:
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批准号:nhmrc : 1102617
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项目类别:Research Fellowships
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资助金额:$42.93万
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财政年份:2016
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负责人:Prof Allison Cowin
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依托单位:
Plasma-soft tissue interactions: advancing a new era of plasma technologies
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批准号:DP160104298
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财政年份:2016
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负责人:Prof Allison Cowin
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依托单位:
New approaches for improving wound repair
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批准号:nhmrc : GNT1102617
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项目类别:Research Fellowships
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资助金额:$62.27万
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财政年份:2016
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负责人:Prof Allison Cowin
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依托单位:
Flightless I, A target for new wound therapies
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批准号:nhmrc : 1002009
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项目类别:Research Fellowships
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资助金额:$42.11万
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财政年份:2011
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负责人:Prof Allison Cowin
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依托单位:
Flightless I, a terget for new wound therapies
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批准号:nhmrc : 508004
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项目类别:Career Development Fellowships
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资助金额:$22.66万
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财政年份:2008
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负责人:Prof Allison Cowin
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依托单位:
海外基金