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Development of Flightless antibody therapy for treating wounds

Development of Flightless antibody therapy for treating wounds
开发用于治疗伤口的Flightless抗体疗法
批准号:
nhmrc : 508006
负责人:
Prof Allison Cowin
金额:
$12.94万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Development Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

项目摘要

项目成果

Prof Allison Cowin的其他基金

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中文摘要
翻译
慢性伤口、糖尿病溃疡、创伤、烧伤和烫伤引起的伤害形成了医疗需求,随着人口老龄化和糖尿病流行病的增长,这种需求只会扩大。在我们的研究中,我们已经表明,Flightless I(FliI),一种肌动蛋白重塑蛋白,是切口伤口愈合的负调节因子。我们现在正在开发一种新的抗体疗法,以降低伤口中的FliI水平,从而改善伤口修复结果。
英文摘要
Chronic wounds, diabetic ulcers, injuries in response to trauma, burns and scalds form a medical need which will only expand as the population ages and the diabetic epidemic grows. In our studies, we have shown that Flightless I (FliI), an actin-remodelling protein, is a negative regulator of incisional wound healing. We are now developing a new antibody therapy to reduce FliI levels in wounds thereby leading to improved wound repair outcomes.
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Modulating sphingolipid signalling to enhance wound healing
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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  • 负责人:
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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海外基金