INFORMATION PROCESSING IN THE COCHLEAR NUCLEUS

这个项目将研究耳蜗核的复杂信号处理。 在那里，平行和分层听觉级联的第一步 信号处理事件就会发生。不同的解剖细胞类型，每种 用不同的靶材，形成平行和顺行的衬底 利用丰富的核内电路网络，形成 投射细胞。目前的目标是：使结构/功能 允许对解剖细胞进行生理学识别的相关性 类型，并探索这些类型如何处理复杂的声音，包括 调幅、N次谐波分量和语音刺激。 细胞外和细胞内记录将与 神经生物素标记建立五种化合物的结构-功能关系 不太清楚的细胞组：(1)起病细胞 PVCN：O/I和O/L模式由哪个细胞组(S)负责 它们与O/C细胞有什么关系？(2)初级类反应，PL， AvCN中的PL/N和O/L来源于浓密的细胞，但有区别 仅凭对音调的反应往往很难做到这一点。做 这些模式是由丛生细胞独有的吗？(3)建立 AVCN中持续和瞬时斩波的形态基础。(4) 确定发病分级反应模式、II型单位 DCN内的感受野和结节腹侧细胞是一个整体 相同的细胞组？(5)确定DCN中的侧翻细胞是否响应 对滴答声、调幅、噪波、带凹槽的噪波和/或对侧噪声进行音调 声学刺激。一项新的倡议将调查 对不同语音的神经生理学反应包括 以前的神经生理学研究中没有使用过的声音。 检查大量的速度声音阵列将使 将结果外推到语音感知。心理物理学 能力将在栗鼠身上作为行为的附属物进行研究 使用相同语音的神经反应的研究 这将在神经生理学研究中公布。在许多情况下， 从一系列语音刺激中提取的对刺激的神经反应 从一个音素到另一个音素不同，这包含了动物的 行为衍生的阈值将得到最深入的研究。 神经反应的信息论计算分析将是 用于实现从神经编码到感觉能力的直接推理。

This project will study complex signal processing in the cochlear nucleus where the first steps of a cascade of parallel and hierarchical auditory signal processing events take place. Distinct anatomical cell types, each with different targets, form the substrate for parallel pathways and along with a rich network of intranuclear circuits shape the outputs of projecting cells. The present aims are: to make structure/function correlations that allow physiological identification of anatomical cell types and to explore how these types process complex sounds including amplitude modulation, N-harmonic component, and speech stimuli. Extracellular-and intracellular-recording will be combined with neurobiotin labeling to establish structure- function relations for five groups of cells that are not well understood: (1) Onset cells in the PVCN: What cells group(s) are responsible for O/I and O/L patterns and what is their relation to O/C cells? (2) The primary-like responses, PL, PL/N, and O/L, in the AVCN arise from bushy cells but distinguishing between them is often difficult based on responses to tones alone. Do these patterns arise from bushy-cells exclusively? (3) Establish the morphological basis for sustained and transient choppers in the AVCN. (4) Establish whether onset-graded response patterns, units with type II receptive fields and tuberculoventral cells in the DCN are one and the same cell group? (5) Establish whether cartwheel cells in the DCN respond to tones clicks, AM, noise, noise with notches, and/or contra-lateral acoustic stimulation. A new initiative will investigate neurophysiological responses to a diverse set of speech sounds including sounds that have not been used in previous neurophysiological studies. Examining a large array of speed sounds will make possible the extrapolation of results to speech perception. Psychophysical capabilities will be studied in the chinchilla as a behavioral adjunct to investigations of neural responses to speech using the same speech sounds that will be presented in the neurophysiological studies. In many cases, neural responses to stimulus pairs, drawn from series of speech stimuli varying from one phoneme to another, that bracket the animal's behaviorally derived thresholds will be most intensely studied. Information-theoretic computational analyses of neural responses will be used to enable direct inference from neural encoding to sensory capacity.