EFFECTS OF DENTAL TREATMENT DURING PREGNANCY ON CHILDHOOD DEVELOPMENT

工作总结：雅芳纵向研究 妊娠与儿童(ALSPAC)是一种独特的 14,000名母亲第一次怀孕时登记的怀孕 怀孕了，现在他们的孩子继续怀孕 随着他们接近上学年龄，他们紧随其后。我们正在与 ALSPAC的研究人员研究了一项关于 在怀孕期间做牙科手术 童年发展。在英国，许多女性 在怀孕期间额外的牙齿护理，当他们的保险覆盖范围是 增加了。水银蒸气可以穿过胎盘，但目前尚不清楚 是否对胎儿有任何不良影响。有牙科 怀孕期间所做的工作也可能通过 通过血液传播感染。我们最近收到了 我们将用来观察牙科治疗效果的数据集 孕期对婴儿发育的影响。该数据集包含 关于运动和认知里程碑的问题，改编自 丹佛发育筛查测验，关于气质和 改编自凯里婴儿气质的行为 问卷调查，以及改编自 麦卡图尔婴儿沟通问卷。大约在1500 在儿童中，我们还将有关于 脐带本身。我们寻找脐带水银的预测因子 水平和使用回归模型发现，鱼的消费， 嘴里含4个或4个以上的汞合金，正在做牙科手术 在怀孕期间做与脐带汞含量增加有关 级别。这是首批使用脐带水汞水平作为 汞蒸汽暴露的标记(它以前曾被用作 甲基汞的标记)。

Summary of Work: The Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC) is a unique prospective of pregnancy in which 14,000 mother's were enrolled when they first became pregnant and now their children have continued to be followed as they approach school age. We are collaborating with researchers from the ALSPAC study on a study of the effect of having dental work done during pregnancy on subsequent childhood development. In Great Britain, many women receive extra dental care during pregnancy when their insurance coverage is increased. Mercury vapor can cross the placenta but it is not known whether there are any adverse effects on the fetus. Having dental work done during pregnancy could also affect the fetus by spreading infection through the bloodstream. We recently received a data set that we will use to look at the effect of dental treatment during pregnancy on infant development. The data set contains questions on motor and cognitive milestones adapted from the Denver Developmental Screening Test,on temperament and behavior that were adapted from the Carey Infant temperament Questionnaire, and speech and language development adapted from the McCarthur infant communication questionnaire. On about 1500 of the children, we will also have data on the mercury levels in the umbilical cord itself. We looked for predictors of cord mercury levels and using regression models found that fish consumption, having 4 or more amalgams in one's mouth and having dental work done during pregnancy were related to increased cord mercury levels. This is one of the first studies to use cord mercury levels as a marker for mercury vapor exposure (it had been used before as a marker of methyl mercury).