THERMODYNAMIC STABILITY OF SEMIQUINONES AS A FUNCTION OF THEIR ENVIRONMENT

半醌类是重要的中间体，被假定涉及在 含醌类药物的细胞毒活性。 这些的功效 活动应取决于热力学稳定性的 半醌。 这种稳定性取决于其内部结构。 半醌和半醌环境违规行为。 是 该子项目的目的是确定热力学参数 控制半醌的内部稳定性以及 半醌与环境的相互作用 一旦这些热力学参数已知， 半醌与氧的氧化还原反应，包括脂质过氧化， 将被确定。 学生将在这个子项目中接受培训， 生物医学研究过程的各个方面，目的是 促进他们的生物医学研究事业。

Semiquinones are important intermediates postulated to be involved in the cytotoxic activities of quinone-containing drugs. The efficacy of these activities should depend on the thermodynamic stability of the semiquinones. This stability depends on the internal structure of the semiquinones and on the semiquinone-environment infractions. It is the purpose of this subproject to determine the thermodynamic parameters controlling the internal stability of semiquinones as well as semiquinone-environment interactions. Once these thermodynamic parameters are known, their effect on semiquinone redox reactions with oxygen, including lipid peroxidation, will be determined. Students will be trained in this subproject in all the aspects of the biomedical research process with the purpose of promoting them to biomedical research careers.