CORONARY ATHEROSCLEROSIS IN FEMALE MONKEYS

绝经后雌激素和乳腺癌之间 妇女冠心病发病率下降。 据估计，减少的幅度从50%到70%不等。 贫困 绝经后妇女对雌激素替代疗法的依从性 防止了对公共卫生的重大影响，因为只有大约8%的妇女 多年来持续治疗， 心脏病和骨质疏松症是重要的。 我们已经寻求确定一种替代方案， 女性可以接受，并且仍然提供对冠心病的保护 疾病和骨质疏松症。 具体来说，我们建议比较 结合马雌激素的治疗/预防益处， 大豆雌激素预防绝经后冠状动脉粥样硬化 动脉粥样硬化/功能障碍、骨质疏松症和乳腺， 子宫内膜增生/发育不良（猴研究），并比较其 对颈动脉粥样硬化进展的影响， 密度和生活质量/依从性问题（人类研究）。 的 基本原理是基于这些化合物的假定保护作用 预防乳腺癌和骨质疏松症的发展，可能缺乏 对子宫的有害影响，以及假设 对冠状动脉粥样硬化可能有利的作用。 该计划项目利用我们机构的能力 在人类和非人类灵长类动物中进行随机试验， 探索哺乳动物和植物雌激素作用机制的能力 对动脉粥样硬化形成和血管功能的影响。

There is a well-established association between postmenopausal estrogen replacement and decreased rates of coronary heart disease among women. Estimates of reduction range from about 50% to as much as 70%. Poor compliance with estrogen replacement therapy by postmenopausal women has prevented a major impact on the public health since only about 8% of women continue the treatment over the years in which prevention of coronary heart disease and osteoporosis are important. We have sought to identify an alternative regimen that would be more acceptable to women and still provide protection against coronary heart disease and osteoporosis. Specifically, we propose to compare the therapeutic/prophylactic benefits of conjugated equine estrogens and soybean estrogens in the prevention of postmenopausal coronary artery atherosclerosis/dysfunction, osteoporosis, and mammary gland and endometrial hyperplasia/dysplasia (monkey studies) and compare their effects on progression of carotid artery atherosclerosis, changes in bone density, and quality of life/compliance issues (human studies). The rationale is based upon the putative protective effect of these compounds against the development of breast cancer and osteoporosis, the likely lack of a harmful effect on the uterus, and an experimental basis for assuming probable favorable effects on coronary artery atherosclerosis. The Program Project takes advantage of the capabilities of our institution in conducting randomized trials in both human and nonhuman primates and the capabilities for exploring mechanisms of mammalian and plant estrogen effects on atherogenesis and vascular function.