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EICOSANOID METABOLISM IN HUMAN MONOCYTES & ALVEOLAR MACROPHAGE BY HIV INFECTION

EICOSANOID METABOLISM IN HUMAN MONOCYTES & ALVEOLAR MACROPHAGE BY HIV INFECTION
人类单核细胞中的二十烷酸代谢
批准号：
6113390
负责人：
MICHAEL J. COFFEY
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6113390
关键词：
HIV infections alveolar macrophages clinical research diagnostic respiratory lavage eicosanoid metabolism helper T lymphocyte human subject leukocyte count lipoxygenase monocyte prostaglandin endoperoxide synthase

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中文摘要
翻译
本研究旨在探讨HIV在单核细胞（PBM）和肺泡巨噬细胞（AM）中增加环氧化酶（考克斯）和减少5-脂氧合酶（5-LO）代谢的机制。 具体目标是：1）与正常受试者相比，比较来自健康HIV+受试者的自体AM和PBM中的考克斯和5-LO代谢以及考克斯和5-LO酶的表达。这将在不同严重程度的2组中进行检查，如通过CD 4 + T淋巴细胞计数所证明的; 2）确定来自HIV+的支气管肺泡灌洗液中的类花生酸水平。
英文摘要
This study proposes to examine the mechanisms by which HIV increases cyclooxygenase (COX) and decreases 5-lipoxygenase (5-LO) metabolism in 1) monocytes (PBM) 2) alveolar macrophages (AM). The specific aims are to: 1) compare COX and 5-LO metabolism and expression of COX, and 5-LO enzymes in autologous AM and PBM from healthy HIV+ subjects as compared to normal subjects. This will be examined in 2 groups of varying severity as evidenced by the CD4+ T lymphocyte cell count; 2) determine the level of eicosanoids in bronchoalveolar lavage fluid from the HIV+.
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