ENDOSCOPIC SPHINCTEROTOMY FOR SPHINCTER OF ODDI DYSFUNCTION

内窥镜乳头括约肌切开术(ES)被证明是一种有效的治疗Oddi括约肌功能障碍患者的胆源性疼痛的方法，这种疼痛是由内窥镜逆行胆道造影(ERC)时基线括约肌压力升高所定义的。最近的研究表明，Oddi括约肌测压在预测ES的反应方面既不是100%灵敏的，也不是100%特异的；此外，ES在临床括约肌功能障碍和测压正常的患者中的疗效在很大程度上还没有研究。我们推测，在这一未被研究的患者群体中，与假括约肌切开术相比，内窥镜括约肌切开术将导致显著的疼痛缓解和生活质量改善。

Endoscopic sphincterotomy (ES) has been shown to be an effective treat- ment for relieving biliary-type pain in patients with sphincter of Oddi dysfuntion defined by elevated baseline sphincter pressures at the time of endoscopic retrograde cholangiography (ERC). Recent studies suggest that sphincter of Oddi manometry is neither 100% sensitive nor specific in predicting response to ES; further the efficacy of ES in patients with clinical sphincter dysfunction and normal manometry is largely unstudied. We theorize that endoscopic sphincterotomy will result in significant pain alleviation and improved quality of life when compared to sham sphincterotomy in this previously unstudied patient population.