EFFECTS OF CHRONIC CONSUMPTION OF MEALS CONTAINING PLANT OR ANIMAL PROTEIN

从植物和动物中获取蛋白质的饮食 在NIDDM患者中具有有益的肾脏和代谢作用， 微量白蛋白尿？ 这是一项交叉研究，每名受试者 作为他/她自己的对照，以随机顺序进食6周的膳食， 含动物（肉，奶）和6周植物（大豆类产品） 蛋白 膳食将在GCRC准备，将是营养的 除了蛋白质来源外，其他都是一样的，可以在家吃。 研究 将在GCRC中进行。 受试者为24名男性和女性， 年龄在35岁和75岁之间的NIDDM和微量白蛋白尿，饮食治疗 或饮食加口服抗糖尿病药物。 主要结果指标为 a）空腹和餐后肾血流动力学（GFR，RPF），24小时尿 尿尿素氮、白蛋白排泄率和肌酐; B） 空腹总胆固醇、HDL-c、LDL-c和甘油三酯，以及餐后 甘油三酯; c）胰岛素、葡萄糖、HbA 1c。和氨基酸谱。 到 确定植物蛋白饮食是否长期有益 治疗高风险NIDDM患者，将分析数据， 饮食对空腹和餐后肾血流动力学、激素 氨基酸谱、脂质代谢和AER的顺序变化。

Will diets which derive their protein content from plant vs animal sources have beneficial renal and metabolic effects in individuals with NIDDM and microalbuminuria? This is a crossover study in which each subject serves as his/her own control by eating, in random order, 6 weeks of meals containing animal (meat, milk) and 6 weeks of plant (soy type products) protein. Meals will be prepared in the GCRC, will be nutritionally equivalent except for protein source, and will be eaten at home. Studies will be conducted in the GCRC. Subjects are 24 males and females between the ages of 35 and 75 with NIDDM and microalbuminuria, treated with diet or diet plus oral anti-diabetic medication(s). Main outcome measures are a) fasting and postprandial renal hemodynamics (GFR, RPF), 24-hr urines for urine urea nitrogen, albumin excretion rate, and creatinine; b) fasting total cholesterol, HDL-c, LDL-c and triglyceride, and postprandial triglycerides; c) insulin, glucose, HbA1c. and amino acid profiles. To establish whether plant protein diets are beneficial in long term treatment of high risk individuals with NIDDM, data will be analyzed for dietary effects upon fasting and postprandial renal hemodynamics, hormonal and amino acid profiles, lipid metabolism, and sequential changes in AER.