MASS SPECTRAL STUDIES OF PORPHYRINS & CHLOROPHYLLS

卟啉，叶绿素和细菌叶绿素是复杂的 具有重要生物学意义的芳族大环，和 还具有新颖的和理论上有趣的质谱。 在 只有少量天然四吡咯 质谱法实际上是唯一可以 用于获取我们材料的结构数据。 初级 来自质谱的信息提供了关于各种 大环上的取代基，因为环通常不 碎片 质谱也有助于确定 未知（合成或生物）卟啉和叶绿素， 意想不到的反应产物或以前未知的天然物质。 我们在加州大学戴维斯分校的团队专注于合成和 卟啉和二氢卟酚系统的生物合成研究， 血红蛋白，肌红蛋白，细胞色素，过氧化氢酶， 过氧化物酶、叶绿素和细菌叶绿素。 我们也 大量参与表征和使用天然来源的 用于恶性肿瘤的光动力疗法的光敏剂。 在这些四吡咯系统中的质谱已经显示，超过 这些年来，成为光谱学的一个至关重要的组成部分， 用于结构研究和化学反应的武器库。

Porphyrins, chlorophylls, and bacteriochlorophylls are complex aromatic macrocycles which are of great biological significance, and also have novel and theoretically interesting mass spectra. In the situation where only small amounts of natural tetrapyrroles are available, mass spectrometry is virtually the only technique which can be used to obtain structural data on our materials. Primary information from mass spectrometry affords information on the various substituents on the macro-ring because the ring does not normally fragment. Mass spectra also help to establish the structures of unknown (synthetic or biological) porphyrins and chlorophylls be they unexpected reaction products or previously unknown natural substances. Our group in UC Davis focusses its efforts on synthetic and biosynthetic studies of porphyrins and chlorin systems which are the prosthetic groups in hemoglobins, myoglobins, cytochromes, catalases, peroxidases, chlorophylls, and bacteriochlorophylls. We are also heavily involved in the characterization and use of naturally derived photosensitizers for use in photodynamic therapy of malignant tumors. Mass spectrometry in these tetrapyrrole systems has been shown, over the years, to be a vitally important component of the spectroscopic arsenal for structural investigation and chemical reactivity.