DEVELOPMENTAL TOXICITY

描述：初步研究表明，2，2，4，4，5，5-六氯苯 显著抑制3，3，4，4，5-五氯苯的致畸作用 未来的合作研究将进一步表征 这些非相加的相互作用。黄曲霉毒素的发育毒性 氯代酚，这是木材防腐的主要成分 利用一系列发育毒性进行了研究。 分析，包括在大鼠体内的第二部分研究，水合试验，HEPM， 和全胚胎培养。这些化合物在初选中的作用 细胞培养生物分析将在未来的研究中进行。现场- 实用的检测方法(微柱分析)和 霉菌毒素的解毒(粘土矿物)已经开发出来， 由菲利普斯博士申请专利。基本技术已经获得许可，并 商业产品目前正在全球范围内使用。建议数 该计划项目的研究将进一步加强这一诊断 测定氯苯酚(CPS)，并利用粘土技术 CPS等卤代芳香烃的降解 (HAHS)与油性和木材保存废物有关。

Description: Preliminary studies indicated that 2,2,4,4,5,5- HCB significantly inhibited 3,3,4,4,5-pentaCB-mediated teratogenicity and future collaborative studies will further characterize the nature of these non-additive interactions. The developmental toxicity of chlorinated phenols, which are major components of wood-preserving wastes, was investigated using a series of developmental toxicity assays, including in vivo segment II studies in rats, hydra assay, HEPM, and whole embryo culture. The effects of these compounds in primary cell culture bioassays will be carried out in future studies. Field- practical methods for the detection (minicolumn assays) and detoxification (clay minerals) of mycotoxins have been developed and patented by Dr. Phillips. The basic technologies have been licensed and commercial products are currently being used worldwide. The proposed research in this program project will further enhance this diagnostic assay for chlorophenols (CPs) and also utilize clay-based technology for the degradation of CPs and other halogenated aromatic hydrocarbons (HAHs) associated with oily and wood-preserving wastes.