ZUNI KIDNEY PROJECT - FAMILY STUDIES

祖尼普韦布洛位于新墨西哥州，人口为11500人。几百年来，这个与世隔绝的小种群一直保持着相对的内婚制。祖尼的终末期肾病患病率分别是美国白人和综合美国印第安人的11倍和4倍。非胰岛素依赖型糖尿病在祖尼人中的患病率很高，流行的主要原因是糖尿病肾病。Zuni几乎每个人都有一位患有终末期肾病的亲戚，这导致了社区对肾脏研究的大力支持。针对这一需要，我们设立了祖尼肾脏项目，该项目正在对所有5岁以上的祖尼居民进行基于人口的调查。我们正在确定所有参与者的家族结构，并量化血糖控制、蛋白尿和肾功能。本项目将建立一个DNA储存库，并确定调节糖尿病肾病和中间表型发病和/或进展风险的基因组片段和环境-遗传相互作用。我们的调查团队包括来自Zuni Pueblo、新墨西哥大学健康科学中心、印度健康服务、西南生物医学研究基金会、NIDDK凤凰城办事处、宾夕法尼亚大学强心脏研究中心和圣拉斐尔科学研究所的代表。这种协作方法使我们能够直接将在Zuni获得的结果与在PIMA印第安人和强心脏研究参与者中获得的结果进行比较。在这些美洲原住民群体中获得的结果将与其余参与调查中心研究的其他种族群体的结果进行比较。

The Zuni Pueblo, located in New Mexico, has a population of 11,500. This small, isolated population has been relatively endogamous for several hundred years. The prevalence of end-stage renal disease at Zuni is 11- and 4- fold higher the U.S. White and composite American Indian rates, respectively. The prevalence of non-insulin-dependent diabetes mellitus is high among the Zuni and the epidemic is attributable mainly to diabetic nephropathy. Almost everyone at Zuni has a relative with ESRD, leading to strong community support for renal research. In response to this need we established the Zuni Kidney Project which is conducting a population-based survey of all Zuni residents greater than or equal to 5 years of age. We are ascertaining family structure and quantifying glycemic control, proteinuria, and renal function in all participants. The present project will establish a DNA repository and identify genome segments and environmental-genetic interactions that modulate the risk for the onset and/or progression of diabetic nephropathy and intermediate phenotypes. Our investigative team includes representatives from the Zuni Pueblo, University of New Mexico Health Sciences Center, Indian Health Service, Southwest Foundation for Biomedical Research, Phoenix office of NIDDK, Strong Heart Study, University of Pennsylvania, and the Istituto Scientifico H San Raffaele. This collaborative approach allows us to directly compare results obtained in the Zuni with those in Pima Indians and Strong Heart Study participants. Results obtained in these Native American populations will be compared with those in other ethnic groups studied by the remaining participating investigating centers.