CARDIOVASCULAR DISEASE IN SIOUX INDIANS

“强壮心脏研究”是一项关于美洲印第安人心血管疾病的研究，涉及亚利桑那州、俄克拉荷马州、北达科他州和南达科他州的13个印第安人社区。第一阶段，开始于1988年10月1日，包括一项医学审查，以确定1984年至1988年期间45至74岁的个体CVD的死亡率和发病率。在达科他中心，对1522名来自奥格拉哈苏族、夏延河苏族和精神湖部落的成员进行了体检，以测量心血管和外周血管疾病的患病率，以及已知和疑似的危险因素。对1993-1995年和1997-1999年该队列的存活余烬进行了随访检查（第II期和第III期）。此外，包括258名研究参与者亲属和68名原始队列参与者（共326名）的9个家庭被纳入与CVD及其危险因素相关的遗传因素的试点家庭研究。本申请提出了在达科他州进行的强心研究的扩展（第四阶段）。第三阶段检查的家庭成员的目的是重新检查326名家庭成员，并检查30个家庭中的另外900名家庭成员。对1226名家庭成员的检查将包括心脏和颈动脉超声检查、心电图、应用眼压计、血液化学、脂质和DNA。扩大家庭研究将允许全面调查心血管疾病的遗传决定因素。

The Strong Heart Study, a study of cardiovascular disease (CVD) among American Indians, involves 13 Indian communities in Arizona, Oklahoma and North and South Dakota. Phase I, which began on October 1, 1988 included a medical review to determine mortality and morbidity for CVD in individuals age 45 to 74 years old between 1984 to 1988. In the Dakota Center, a physical examination was performed on 1522 members of the Oglaha Sioux, Cheyenne River Sioux and Spirit Lake Tribes, to measure prevalence and cardiovascular and peripheral vascular disease, and known and suspected risk factors. Follow up exams (Phase II and Phase III) were conducted on surviving embers of this cohort from 1993-1995 and 1997-1999. In addition, nine families that included 258 relatives of study participants and 68 of the original cohort participants (326 total) were included in the pilot Family Study of genetic factors related to CVD and its risk factors. This application proposes an extension (Phase IV) of the Strong Heart Study in the Dakotas The aims of family members examined in Phase III, to re-examine those 326 family members and to examine an additional 900 family members in 30 more families. The examination of the 1226 family members will include cardiac and carotid ultrasound studies, EKGs, applination tonometry, blood chemistries and lipids and DNA. Expanding the family study will allow complete investigation of genetic determinants of CVD.