Nuclear force feedback as rheostat for actomyosin tension control

衰老在身体的多个层面上表现出来。许多细胞类型，如血管和邻近细胞，由于血流和收缩而受到持续的机械挑战。在细胞中，衰老和早衰综合症（如早衰症）会引起一些变化，使它们在受到压力时更容易受到损害。在这个项目中，我们将研究细胞如何调节它们对压力的反应，以及为什么这在衰老细胞中不起作用。我们发现，细胞骨架——保持细胞形状和运动的支架——承受着更大的压力，经历着衰老的症状。这导致细胞对施加在细胞上的各种外部力量的反应能力下降，并经常导致细胞死亡。在这个应用中，我们将研究这种对力的适应性降低的原因。这将有助于了解衰老引起的细胞变化，并可能为开发治疗这些症状的研究提供新的途径。

Ageing manifests itself on multiple levels in the body. Many cell types, such as blood vessel and adjacent cells are subject to constant mechanical challenges due to blood flow and constriction. In cells, ageing and pre-mature ageing syndroms such as Progeria cause several changes that make them more prone to damage when they are put under strain. In this project we are going to investigate how cells regulate their responds to strain and why this does not work in aged cells. We have found that the cytoskeleton, the scaffold that keeps cells in shape and motile, is under more tension that experience symptoms of ageing. This leads to decreased ability to respond to varying outside forces that are applied onto the cells and often causes cell death. In this application we will investigate the cause of this reduced adaptability to force. This will help in understanding the changes that ageing causes in cells and potentially will give rise to new avenues of research into developing treatments for these symptoms.