DNP IN CHAR SUSPENSIONS--SURFACE SCIENCE AND OXIMETRY

该FIRCA应用程序的父项目使用电子和核 磁共振方法来研究的结构和有效性 用于临床MRI的作为顺磁性造影剂的无机复合物 使用. 这项拟议中的合作将研究一类新的氧- 敏感的探针，最终目标是使用这些碳物种， 动态核极化（DNP）成像、EPR和DNP血氧测定 应用. 总体目标是提高 这些潜在的新型造影剂在MRI临床应用中 （成像和血氧测定。） 工作假设是，通过研究 整个类别的炭悬浮液（其中大部分以前已经被 合成）在各种实验条件下（高场、低场 场，可变温度），他们最终将能够更充分地 理解（并可能能够优化）电子核 多相系统中的偏振传递过程。

The parent project for this FIRCA application uses electron and nuclear magnetic resonance methods to study the structure and effectiveness of inorganic complexes as paramagnetic contrast agents for clinical MRI use. This proposed collaboration will study a new class of oxygen- sensitive probes, with the ultimate goal of using these char species for Dynamic Nuclear Polarization (DNP) imaging, EPR and DNP oximetry applications. The overall goal is to increase the effectiveness of these potentially new contrast agents in MRI clinical applications (imaging and oximetry.) The working hypothesis is that by studying the whole class of char suspensions (most of which have previously been synthesized) under a variety of experimental conditions (high field, low field, variable temperature) they will ultimately be able to more fully understand (and possibly be able to optimize) the electron-nuclear polarization transfer process in multiple-phase systems.