PRINCIPALS OF CONFORMATIONAL ANALYSIS OF CARBOHYDRATES--A TEXTBOOK

碳水化合物在几个生物过程中的重要性， 很好地建立了。特异性细胞-细胞识别，细胞-基质 附着、细胞-病毒相互作用和生长因子的调节 受体涉及寡糖-蛋白质相互作用。还有， 据报道，寡糖-核酸相互作用 在许多生物过程中起重要作用。所以，知识。 寡糖的精确分子结构及其 相互作用伴侣对于设计抑制剂或 毒品最近，一些工具被用来研究 碳水化合物的构象和与蛋白质的相互作用，但 通过理论技术进行构象分析是重要的 贡献，并已被公认为一个重要的 调查工具。理论研究，特别是应用 构象能的计算使得预测 即使是那些碳水化合物的可能结构， 可溶且难以结晶。这在很大程度上有助于 以填充由于缺乏足够的X射线衍射而产生的空隙 和核磁共振数据碳水化合物相比，核酸和蛋白质。 目前还没有一本合适的书可以介绍 学生，教师，研究科学家和初学者在这一领域的 研究糖的立体化学， 碳水化合物的构象分析，以可用的方法 用于分析糖的构象。因此，一本书， 这些话题是非常可取的。它恰逢一个及时的 邀请我们的访问科学家V.S.R.博士来自哈伍德的拉奥 学术出版商，荷兰，写一本书的原则， 碳水化合物的构象分析。拉奥博士，来自印第安人 印度班加罗尔科学研究所（I.I.Sc） 系统的方式，研究结构的方法， 低聚糖和长链多糖， 在氧桥上的键的二面角。的 时机已经成熟，可以系统地汇编结构知识， 时尚，并使其易于提供给学生，教师和研究 对碳水化合物结构感兴趣的科学家一样。我们，博士。 V.S.R.Rao，Pradman K博士卡斯巴，Petetty Balaji博士，访问学者 现在是结构糖生物学部的助理教授 在印度孟买的印度理工学院，沿着 R教授来自普渡大学的Anglasekaran成功地 正在写一本关于“碳水化合物的构象”的书， press.

The importance of carbohydrates in several biological processes is now well established. Specific cell-cell recognition, cell-substratum attachment, cell-virus interactions and modulations of growth factor receptors involve oligosaccharide-protein interactions. Also, oligosaccharide-nucleic acid interactions are being reported to play an important role in several biological processes. Thus, the knowledge of the precise molecular structure of the oligosaccharide and its interacting partner is of great importance for designing inhibitors or drugs. Recently a number of tools are being used to study the conformation of carbohydrates and interactions with proteins, but conformational analysis by theoretical techniques are making important contributions, and have come to be recognized as one of the important investigative tools. Theoretical studies, in particular, the application of conformational energy calculations has made it possible to predict the probable structures of even those carbohydrates which are poorly soluble and difficult to crystallize. This has to a large extent helped to fill up the void created by the lack of sufficient x-ray diffraction and NMR data on carbohydrates as compared to nucleic acids and proteins. At present there is no suitable book available that would introduce the students, teachers, research scientists, and beginners in this field of research to the stereochemistry of sugars, to the principles of conformational analysis of carbohydrates, to the available methods used for the analysis of conformation of sugars. Thus, a book that will deal with these topics is highly desirable. It coincided with a timely invitation to our Visiting Scientist, Dr. V.S.R. Rao, from Harwood academic publishers, The Netherlands, to write a book on the principles of conformational analysis of carbohydrates. Dr. Rao, from the Indian Institute of Science (I.I.Sc), Bangalore, India, has developed in a systematic manner, methods for investigating the structures of oligosaccharides, and long chain polysaccharides by utilizing the idea of dihedral angles around the bonds meeting at the bridge oxygen. The time was ripe to compile the structural knowledge in a systematic fashion, and make it easily available to students, teachers and research scientists alike who are interested in carbohydrate structures. We, Dr. V.S.R.Rao, Dr. Pradman K. Qasba, Dr. Petety Balaji, a Visiting Fellow in the Structural Glycobiology Section and now an Assistant Professor at the Indian Institute of Technology, Bombay, India, along with Professor R. Chandrasekaran from Purdue University, have succeeded in writing the book on the "Conformation of Carbohydrates" which is now in press.