心血管疾病分子遗传学统计分析-猫眼课题宝

心血管疾病分子遗传学统计分析

批准号：

6162612

负责人：

A F WILSON

金额：

$0.0万

依托单位：

NATIONAL HUMAN GENOME RESEARCH INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/6162612

关键词：

African American atrial natriuretic peptide blood pressure cardiovascular disorder clinical research gene expression genetic markers genotype human subject linkage mapping molecular genetics peptidyl dipeptidase A renin angiotensin system sodium potassium exchanging ATPase statistics /biometry

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英文摘要

The purpose of the project is to identify genes involved in cardiovascular disorders using genetic markers and statistical genetic analyses. The markers studied include probes for candidate genes for angiotension converting enzyme, Na-K-ATPase, renin and atrial natriuretic factor, as well as anonymous DNA markers. Using genotyping data from the University of Cincinnati, model-independent sib pair linkage analysis was used to identify possible regions involved in the variation of blood pressure measures. The sample includes over 100 sib pairs, primarily African-Americans.

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