PATERNALLY-MEDIATED EFFECTS ON REPRODUCTION

工作总结：从历史上看，遗传和环境的研究 影响生殖和随后发育的因素 后代以女性为中心。 经过长达一年的评估 然而，在世界文献中，需要进行流行病学研究， 男性介导的生殖结果是明确的。 因此我们有 从欧洲妊娠纵向研究中获得数据， 童年在英国布里斯托进行（“ALSPAC”）。 在ALSPAC 一项研究发现，雅芳有超过7,000名分娩妇女的伴侣 1991年至1992年期间，英格兰郡提供了终身职业和有毒 暴露历史 婴儿和他们的父母将被跟踪， 七年我们对两个母亲的职业历史进行了编码， 父亲，使用英国标准职业代码，并分类 在工作和家庭中自我报告的暴露。 今年完成了四项研究;一项研究仍在进行中。一 研究表明父亲的职业与胎儿的生长发育无关。 一篇使用母亲职业数据的论文报告了同样的结果 （已提交）。 父亲和母亲对他的报告之间的一致性 第三项研究正在审查职业问题，这项研究仍在进行中。 一 关于生殖腺辐射用于医疗目的的论文揭示了 提示但不显著的胎儿生长下降。最后，一张纸 对流产妇女暴露回忆的准确性， 出版物;妇女报告说，更多的接触之前，他们流产， 当被问到同样的问题时

Summary of Work: Historically, research on genetic and environmental factors affecting reproduction and subsequent development of the offspring has been centered on the female. After a year-long assessment of the world literature, however, the need for an epidemiologic study of male-mediated reproductive outcomes was clear. Therefore we have obtained data from the European Longitudinal Study of Pregnancy and Childhood being conducted at Bristol, England ("ALSPAC"). In the ALSPAC study, more than 7,000 partners of women who delivered infants in Avon County, England during 1991-2 provided lifetime occupational and toxic exposure histories. The infants and their parents will be followed for seven years. We have coded occupational histories of both mothers and father, using the British Standard Occupational Codes, and categorized the self-reported exposures on the job and in the home. Four studies have been completed this year; one is still in progress. One study reports no association of paternal occupation with fetal growth. A paper using maternal occupational data reports the same result (submitted). The concordance between father's and mother's report of his occupation is being examined in the third study, still in progress. A paper on radiation to the gonads for medical purposes reveals a suggestive but non-significant decrease in fetal growth. Finally, a paper on accuracy of exposure recall in women who miscarry was accepted for publication; women reported more exposures before they miscarried than when asked the same questions after the event occurred.