TOXICANTS IN HUMAN PLACENTA AND REPRODUCTIVE OUTCOMES IN UKRAINE

工作总结：在新独立的乌克兰， 环境污染严重；污染不仅是由于 切尔诺贝利事故，但对集约化农业实践和 过时的工业技术。这项研究的目的是描述 分娩妇女胎盘和乳汁中毒物的负担 在这种情况下的婴儿，并记录他们的生殖 结果。据我们所知，这是第一个以人口为基础的 对前苏联国家妊娠结局的描述。 为了实现这些目标，我们正在与乌克兰合作 “ELSPAC”研究--世界首创的几项欧洲研究之一 卫生组织。我们已经获取了胎盘和牛奶样本 超过2200名女性在两个研究地点分娩。随机抽样200人 对其中的金属、卤代烃和 多环芳香烃；这将使我们能够避免 对额外的样品进行不必要的检测。这些医疗记录 妇女被抽象化，关于母亲生活方式的问卷数据 获得。从这些女性中抽出的人口是 从妊娠结局的角度描述。来自这两家公司的环境数据 对进行这项研究的乌克兰城市进行了分析。 正在进行方法学检查，以确认数据的质量。分析 数据的更新正在进行中。

Summary of Work: In the newly independent country of Ukraine, environmental pollution is severe; the contamination is due not only to the Chernobyl accident, but to intensive agricultural practices and outmoded industrial technology. The purpose of this study is to describe the burden of toxicants in placentas and milk of women who deliver infants in such circumstances, and to document their reproductive outcome. To our knowledge, this is the first population-based description of pregnancy outcome in a former Soviet country. To accomplish these aims, we are collaborating with the Ukrainian "ELSPAC" study, one of several European studies initiated by the World Health Organization. We have obtained placenta and milk samples from over 2,200 women who delivered in two study sites. A random sample of 200 of these have been analyzed for metals, halogenated hydrocarbons, and polycyclic aromatic hydrocarbons; this will enable us to avoid unnecessary assays for the additional samples. Medical records these women have been abstracted, and questionnaire data on maternal lifestyle obtained. The population from which the women were drawn has been described in terms of pregnancy outcome. Environmental data from the two Ukrainian cities in which the study was conducted have been analyzed. Methology checks to confirm quality of data are being conducted. Analysis of the data is proceeding.