IDENTIFICATION OF GENES FOR HYPERTENSION/SALT SENSITIVITY IN AFRICAN AMERICANS

之前与Svetkey博士的合作提出了关联的证据 在5号染色体上位于或靠近β-2-肾上腺素能的标记之间 受体，至少在一定程度上对表型负有责任 盐负荷和盐耗竭后舒张压的变化。 对推测的基因座两侧的标记进行额外的基因分型未能 显示有关联的证据，尽管之前的发现得到了证实 采用连锁分析中的方差成分分析方法。估计 侧翼标记之间的重组分数相当大 在这个以女性为主的非裔美国人中， 在其他人群中也有报道。对遗传力的估计表明，在 至少有一些与盐敏感有关的性状是高度敏感的， 这表明遗传成分可能在 盐负荷后血压的变化。

Previous collaborations with Dr. Svetkey suggested evidence for linkage between a marker on chromosome 5, at or near the beta-2-adrenergic receptor, that was responsible, at least in part, for the phenotypic variation of diastolic blood pressure after salt loading and depletion. Additional genotyping of markers flanking the putative locus failed to show evidence of linkage, although the previous finding was corroborated using the variance-components method of linkage analysis. The estimated recombination fractions between the flanking markers were considerably larger in this population of predominantly female African-Americans than reported in other populations. Estimates of heritability suggest that at least some of the traits related to salt- sensitivity are high, suggesting that genetic components may play a substantial role in the expression of blood pressure after exposure to salt loading.