NEUROMUSCULAR STIMULATION FOR THE CONTROL OF VOICE AND SWALLOWING

工作总结： 该项目正在评估神经肌肉的使用和疗效。 神经假体刺激治疗中枢性运动障碍 影响发声和吞咽的控制障碍。它涉及到一个 与美敦力公司的合作研发协议。 慢性甲状旁肌神经肌肉刺激是 今年在动物模型系统中进行了评估。植入的系统 仍然存活，并保持相同的运动阈值，位移 和速度超过4到8个月，间歇性刺激 甲颧肌。实现双侧甲状旁腺刺激 充分关闭声门以保护呼吸道。目前，运动学 慢性刺激的效果在1)舌骨期间进行评估 肌肉刺激以抬高喉部以便于吞咽和2)侧向 刺激环踝，收拢发声的声带。 临床门诊研究正在评估甲状旁腺素的疗效 健康受试者外环-踝神经肌肉电刺激对发音的影响 志愿者和有外展肌痉挛发音困难的人。一款应用程序 对有声音和吞咽障碍的人进行I期临床试验 失调症计划在明年举行。

Summary of Work: This project is evaluating the use and efficacy of neuromuscular stimulation by a neuroprosthesis in the treatment of central motor control disorders affecting voice and swallowing. It involves a Cooperative Research and Development Agreement with Medtronic, Inc. Chronic neuromuscular stimulation of the thyroarytenoid muscle was evaluated in an animal model system this year. The implanted system remained viable and maintained the same movement threshold, displacement and velocity over 4 to 8 months with intermittent stimulation of the thyroarytenoid muscle. Bilateral thyroarytenoid stimulation achieved adequate glottic closure for airway protection. At present the kinematic results of chronic stimulation are being evaluated during 1) mylohyoid muscle stimulation to elevate the larynx for swallowing and 2) lateral cricoarytenoid stimulation to adduct the vocal folds for voicing. Clinical outpatient studies are evaluating the effects of thyroarytenoid and lateral cricoarytenoid neuromuscular stimulation on voice in healthy volunteers and persons with abductor spasmodic dysphonia. An application for a Phase I Clinical Trial in persons with voice and swallowing disorders is planned for next year.