HORMONE THERAPY AND INFLAMMATORY CELL ADHESION MOLECULES

动脉粥样硬化可能是一种慢性炎症性疾病， 脂蛋白的氧化。 为了研究一种 具有抗氧化潜力的雌激素对慢性前列腺炎可溶性标志物的影响 血管炎症，我们给予17 β-雌二醇， 绝经后妇女，测量细胞粘附分子， 将循环的炎性细胞束缚并结合到血管中 墙 20名妇女被随机分配到开始为期一个月的治疗， 每日0.1 mg透皮17 β-雌二醇（9名女性）或 17 β-雌二醇0.1 mg和醋酸甲羟孕酮2.5 mg，每日一次 (11妇女）。 我们检测了可溶性E-选择素、细胞间粘附 血管细胞粘附分子（VCAM-1） 血清中的浓度，以及低浓度的氧化性 从血浆中分离的脂蛋白（分光光度法二烯形成 试验），设盲 所有检测的性能。 激素治疗显著延长了 低密度脂蛋白氧化开始时间与 治疗前值（77+/-13至88+/-16分钟，p=.003）和轻微 降低了最大氧化速率（p= 0.077）。 激素治疗 ICAM-1水平显著降低8%（p= 0.009）， E-选择素水平降低6%（p=.096），VCAM-1水平降低6%（p=.084）。 醋酸甲羟孕酮联合给药未显示任何 E-selectin、ICAM-1的相对变化有显著性差异 和VCAM-1水平，与单独的17 β-雌二醇相比（所有p> 0.10）。 我们 结论是激素治疗对标志物有良好的影响， 血管炎症，可能减少冠状动脉的变化 绝经后妇女的疾病风险。

Atherosclerosis is likely a chronic inflammatory disease associated with oxidation of lipoproteins. In order to investigate the effect of an estrogen with antioxidant potential on soluble markers of chronic vascular inflammation, we administered 17beta-estradiol to postmenopausal women, with measurement of cell adhesion molecules that tether and incorporate circulating inflammatory cells into the vessel wall. Twenty women were randomized to begin one-month treatment with either transdermal 17beta-estradiol 0.1 mg daily (9 women) or 17beta-estradiol 0.1 mg and medroxy- progesterone acetate 2.5 mg daily (11 women). We measured soluble E-selectin, intercellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) concentrations in serum, and the oxidizability of low density lipoprotein isolated from plasma (spectrophotometric diene formation assay) at baseline and following one month of treatment, with blinded performance of all assays. Hormone therapy significantly prolonged the time to onset of low density lipoprotein oxidation compared with pretreatment values (77+/-13 to 88+/-16 min, p=.003) and marginally reduced the maximum rate of oxidation (p=.077). Hormone therapy significantly lowered ICAM-1 levels by 8% (p=.009) and tended to lower E-selectin levels by 6% (p=.096) and VCAM-1 levels by 6% (p=.084). Co-administration of medroxyprogesterone acetate did not show any significant differences in the relative changes in E-selectin, ICAM-1 and VCAM-1 levels, compared to 17beta-estradiol alone (all p>.10). We conclude that hormone therapy has a favorable effect on markers of vascular inflammation, changes that may reduce the coronary artery disease risk of postmenopausal women.