CANCER BIOLOGY TRAINING PROGRAM

描述（申请人描述）：内布拉斯加州大学医学中心的Eppley癌症中心是美国仅有的10个nci指定的基础实验室癌症中心之一，也是美国心脏地带六个州地区唯一的nci指定的癌症中心。因此，埃普利癌症中心在培养未来的科学家和癌症医生方面发挥着关键的区域作用。申请者还从全国范围内招收博士生和博士后，这丰富了UNMC的研究生培养计划。NCI中心研究培训补助金支持其癌症中心范围的癌症研究培训计划（CRTP）的关键部分，该计划目前有43名博士前研究员和16名博士后在接受培训。埃普利癌症中心目前有108名基础和临床研究教师，他们在广泛的癌症研究培训计划的重要领域拥有广泛的专业知识。这包括合成有机化学、生物化学、结构生物学、分子生物学、细胞生物学、病毒学、免疫学、药理学、病理学和临床肿瘤学。埃普利癌症中心自1984年以来一直是nci指定的癌症中心，在跨学科研究和培训方面有着悠久的历史。癌症中心不授予博士学位，所有进入的研究生都有机会与CRTP教师轮岗，然后在参与部门之一选择论文指导老师：生物化学和分子生物学，病理学和微生物学，药理学或药物科学。他们的一些学员直接参与转译研究活动，例如白血病的基因靶向治疗、儿茶酚类雌激素在人乳腺癌中的作用、放射免疫结合疗法和肿瘤疫苗的开发、妇科癌症肿瘤标志物的开发。支持UNMC/Eppley癌症中心癌症研究培训计划的培训基金的目标是为每位博士生和博士后提供知识基础、实验室技能和解决问题的能力，使他们成为独立、创新的癌症研究人员。培训资助的具体目的是为博士后和博士生提供：1)关于致癌机制、人类癌症流行病学和癌症预防潜力的知识；2)对正常细胞和癌细胞的生物化学、分子、细胞和结构生物学有广泛的了解；3)将这些信息应用于规划和开展癌症病因、预防、诊断和治疗方面的创新研究的能力。为了实现这些目标，CRTP必须能够吸引高素质和积极进取的研究生和博士后，并为他们提供高质量的教学和实验室经验。

DESCRIPTION (Applicant's Description): The Eppley Cancer Center at the University of Nebraska Medical Center is one of only 10 NCI-designated Basic Laboratory Cancer Centers in the U.S. It is the only NCI-designated Cancer Center in a six state region in the heartlands. As such, the Eppley Cancer Center plays a key regional role in training future scientists and cancer physicians. The applicants also recruit from a national pool of predoctoral and postdoctoral fellows, which enriches all the graduate training programs at UNMC. The NCI Center Research Training Grant supports a key part of their Cancer Center-wide Cancer Research Training Program (CRTP) which currently has 43 predoctoral and 16 postdoctoral fellows in training. The Eppley Cancer Center currently has 108 basic and clinical research faculty who have a wide variety of expertise in areas important for a broad-based cancer research training program. This includes synthetic organic chemistry, biochemistry, structural biology, molecular biology, cellular biology, virology, immunology, pharmacology, pathology, and clinical oncology. The Eppley Cancer Center has been an NCI-designated Cancer Center since 1984 and has a long history of interdisciplinary research and training. The Cancer Center does not grant a doctoral degree and all entering graduate students have a chance to rotate with CRTP faculty before they pick a thesis advisor in one of the participating departments: Biochemistry and Molecular Biology, Pathology and Microbiology, Pharmacology, or Pharmaceutical Sciences. A number of their trainees are directly involved in translational research activities, for example, in gene-targeted therapy for leukemia, role of catechol estrogens in human breast cancer, radioimmunoconjugate therapy and tumor vaccine development, and development of tumor markers for gynecologic cancer. The objective of the training grant that supports the UNMC/Eppley Cancer Center Cancer Research Training Program is to provide each doctoral student and postdoctoral fellow with the knowledge base, laboratory skills, and problem solving abilities to become independent, innovative cancer investigators. The Specific Aims of the training grant are to provide pre-and postdoctoral trainees with: 1) knowledge of the mechanisms of carcinogenesis, the epidemiology of human cancer, and the potential for cancer prevention; 2) a broad understanding of the biochemistry, molecular, cellular, and structural biology of normal and cancer cells; and 3) the ability to apply this information to planning and conducting innovative research on the causes, prevention, diagnosis and treatment of cancer. To achieve these objectives the CRTP must be able to attract highly qualified and motivated graduate students and postdoctoral fellows and provide them with high quality didactic and laboratory experiences.