Discovering the genetic causes of congenital heart disease using systems biology

先天性心脏病（CHD）影响一百个活产婴儿中的一个，在澳大利亚和全世界都是一个重大的健康负担。我的研究团队正在使用最先进的DNA测序技术对数百名CHD患者及其家庭成员的整个基因组进行测序。我的研究项目开发快速可靠的计算机软件，以加速冠心病遗传原因的发现，并使基于基因组的个性化医学成为现实。

Congenital heart disease (CHD) affects one in one hundred live-born babies, representing a significant health burden in Australia and worldwide. My research team is using state-of-the-art DNA sequencing technology to sequence the entire genome of hundreds of patients with CHD and their family members. My research program develops fast and reliable computer software to accelerate the discovery of the genetic causes of CHD, and make personalised genome-based medicine a reality.