STRESS RESPONSE AND GROWTH: IMPACT OF EARLY LIFE STRESS

描述：(改编自《调查员摘要》)： 建议是理解关键发育时期的作用， 当改变时，会导致以大鼠为动物模型的生长失败。努力 集中在老鼠发育的两个阶段，即前两个阶段 生命的几周，当压力的激活和终止可以改变的时候 相反的方向，取决于压力源的时机和 断奶后阶段，即大鼠不再依赖母体照料的时期 生死存亡。焦点放在下丘脑、海马体和脑垂体部。 因为这些结构被认为发挥着重要的神经和内分泌作用 控制LHPA和生长激素(GH)轴。建议：1) 检查早期应激的后果(在特定情况下剥夺母亲的权利 生命中的次数)对成长参数的影响；2)检查个体差异 在母亲被剥夺所导致的压力反应中改变 在发育过程中与功能生长激素轴相连的分子的表达；3) 试图通过以下方式扭转剥夺母亲的长期负面影响 在生命早期用CRH拮抗剂阻断LHPA对应激的反应； 4)探索儿童成长过程中的家庭心理病理 评估。

DESCRIPTION: (Adapted from the Investigator's Abstract): The focus of the proposal is to understand the role of critical developmental periods which, when altered, lead to growth failure using the rat as an animal model. Efforts are concentrated on two stages of the rat's development, i.e., the first two weeks of life, when activation and termination of stress can be altered in opposite directions, depending on the timing of stressors and on the post-weaning period when the rat is no longer dependent upon maternal care for survival. Focus is placed upon the hypothalamus, hippocampus, and pituitary because these structures are thought to exert important neural and endocrine control upon the LHPA and the growth hormone (GH) axes. It is proposed to: 1) examine the consequences of early stress (maternal deprivation at specified times in life) on growth parameters; 2) examine if the individual differences in stress responsiveness resulting from maternal deprivation alter the expression of molecules linked to a functional GH axis during development; 3) attempt to revert the long-term negative effects of maternal deprivation by blocking the LHPA response to stress during early life with a CRH antagonist; and 4) explore psychopathology in families of children being seen for growth evaluation.