A longitudinal neuroimaging study investigating reorganisation of cerebellar-cerebral networks in Friedreich ataxia

弗里德赖希共济失调（FRDA）导致衰弱的运动和认知缺陷。我们提出一种纵向多模态磁共振（MR）成像研究来测量这种疾病中不同类型的大脑组织。我们试图了解由于脊髓、小脑和大脑皮层的细胞损失，大脑是如何自我重组的。这项研究将建立一系列磁共振成像测量的敏感性，作为潜在的生物标志物，用于该疾病的大型多中心药物试验。

Friedreich ataxia (FRDA) causes debilitating motor and cognitive deficits. We propose a longitudinal multi-modal magnetic resonance (MR) imaging study to measure different types of tissue in the brain in this disease. We seek to understand how the brain reorganises itself due to cell loss in the spinal cord, cerebellum and cerebral cortex. This study will establish sensitivity of a range of MR imaging measures as potential biomarkers for use in large multi-centre drug trials in this disease.