GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA

PI计划继续他非常成功的研究计划 物种形成的遗传基础。这项基于果蝇的研究 主要集中在非常接近的物种之间的差异， 可能对物种的隔离很重要特别是， 越来越多的证据表明， 合子隔离可能是最常见的和最早出现的形式， 隔离物种形成事件。对与糖尿病相关的表型的研究 最近的物种形成事件可能是复杂的。一类表型是 物种差异可能是进化的一个组成部分， 生殖隔离。这些差异通常是性别限制的， 在这种情况下，至少有四类生物需要研究 （两个物种中的雄性和雌性）。第二类表型 是生物体对的特征（例如，与前 合子限制杂交性别，如配偶选择），有两个 可以考虑每对同胞物种的互惠对。 此外，这些表型通常必须与它们的 种内形式。第三类包括至少两个有趣的 表型只表现在物种杂交，不育和 不能存活这些都可以在正反交中进行研究， 这取决于杂交后代的无活力性和可用于避免 了拟议的研究将集中在这三个表型 分类，使每一个都经历基因图谱协议。

DESCRIPTION: The PI plans to continue his very successful research program on the genetic basis of speciation. This Drosophila based research has primarily focused on differences between very closely related species that may have been important in the isolation of species. In particular, much of the proposed work is motivated by a growing body of evidence that pre- zygotic isolation may be the most common and first arising form of isolation for speciation events. The study of phenotypes associated with recent speciation events can be complex. One class of phenotypes are species differences that may have arisen as a component of the evolution of reproductive isolation. Often these differences are sex-limited so that there are at least four classes of organisms to examine in this context (males and females in each of two species). A second class of phenotype are features of pairs of organisms (e.g. anything associated with pre- zygotic limits to hybrid sex, such as mate choice) and there are two reciprocal pairs that can be considered for each pair of sibling species. Also these phenotypes must usually be measured in comparison to their intra-specific form. A third class includes at least two interesting phenotypes that are only manifest in species hybrids, sterility and inviability. These can be studied in both reciprocal crosses, potentially, depending on hybrid inviability and the genetic tools available to avoid it. The proposed research will focus on phenotypes in each of these three categories, subjecting each to a gene mapping protocol.