The regulation of fearful emotions: novel insights from the female brain

情绪调节中的性别差异被广泛记录在案，但目前的恐惧抑制模型是基于男性大脑的。本项目旨在研究性激素对雌性大鼠恐惧抑制的影响。这个项目意义重大，因为它将导致一个更完整的恐惧抑制神经生物学模型的发展，该模型解释了性的影响。它将创新性地弥合恐惧抑制研究和大脑可塑性荷尔蒙调节之间的差距。这些结果将为自然产生的激素如何改变恐惧抑制提供独特的见解，并可能确定情绪调节和情绪障碍性别差异背后的神经生物学机制。

Sex differences in emotion regulation are widely documented, yet current models of fear inhibition are based on the male brain. This project aims to investigate the impact of sex hormones on fear inhibition in female rats. This project is significant because it will lead to the development of a more complete neurobiological model of fear inhibition that accounts for the impact of sex. It will innovatively bridge the gap between research on fear inhibition and hormonal modulation of brain plasticity. The outcomes will provide unique insights into how naturally occurring hormones alter fear inhibition, and may identify a neurobiological mechanism underlying sex differences in emotion regulation and emotional disorders.