RESEARCH ANIMAL MAGNETIC RESONANCE IMAGING INSTRUMENT

该项目的目标是在加州大学洛杉矶分校医学院建立一个磁共振成像（MRI）实验室。该实验室将容纳并操作4.7特斯拉磁共振成像扫描仪，其直径为40厘米，专为研究动物的调查研究而设计。除了执行高分辨率解剖成像外，该仪器将能够执行各种各样的磁共振成像和光谱研究，这些研究统称为“功能性”MRI。加州大学洛杉矶分校没有这样的仪器，加州大学洛杉矶分校的研究人员也没有接触到这样的仪器，尽管在临床服务MRI扫描仪上进行了一些相关的研究。然而，该项目将由一位在其他机构拥有十几年管理和使用类似仪器经验的首席研究员指导。加州大学洛杉矶分校医学院拥有高度集中的联邦政府支持的研究。该提案描述了加州大学洛杉矶分校正在进行的12项联邦拨款，这些拨款需要拟议的仪器。其中10个是研究经费。两项是培训补助金联邦研究补助金包括各种基本和与健康有关的目标。因此，该设施将成为加州大学洛杉矶分校研究人员的研究资源，他们的研究需要在联邦资助下在自己的实验室研究动物模型的功能和解剖成像。神经科学和基因治疗将是生物成像研究的广泛重点，这些研究将在设施建立后进行。然而，从长远来看，预计生物研究的重点将与实验室的“资源”功能保持一致。卖方列出的仪器成本包括所需的配件超过100万美元。成本加上基本和健康相关的综合目标，使该项目有资格获得双重机构（NCRR和NSF）的考虑。因此要求这两个机构提供最高数额的经费。

The project aim is to establish a magnetic resonance imaging (MRI) laboratory within the UCLA School of Medicine. The laboratory will house and operate a 4.7 Tesla magnetic resonance imaging scanner with a 40 cm clear bore diameter that is specifically designed for investigational studies of research animals. The instrument will be capable of performing a wide variety of magnetic resonance imaging and spectroscopic studies which are collectively referred at as "functional" MRI in addition to performing high resolution anatomic imaging. No instrument of this sort exists at UCLA, nor have UCLA investigators have had access to one, although some related studies have been performed on clinical service MRI scanners. However, the project will be guided by a Principal Investigator who has over a dozen years of experience with the management and use of similar instruments at other institutions. The UCLA School of Medicine houses a high concentration of federally- supported research studies. The proposal describes twelve federal grants which are now underway at UCLA which require the proposed instrument. Ten of these are research grants. Two are training grants The federal research grants include a variety of basic and health-related aims. Hence, the facility will serve as a research resource for UCLA investigators whose research requires functional and anatomic imaging of animal models being studied in their own laboratories under federal sponsorship. Neuroscience and gene therapy will be broad focuses of the biological imaging studies which are undertaken once the facility is established. However, in the long term, a fluid and evolving biological research focus is anticipated in consistency with the "resource" function in the laboratory. The vendor's listed instrument cost including needed accessories is over $1 million. The cost together with the combined basic and health-related goals make the project eligible for dual agency (NCRR and NSF) consideration. Funding at the maximum level from both agencies is thereby requested.