CRYO ELECTRON MICROSCOPY & MACROMOLECULAR IMAGING

本项目的目标是检查职能组织 控制手部和手臂运动的初级运动皮层。 通过 使用多种成像方式，我们将确定 初级运动皮层的激活之间的联系 测量 功能性磁共振成像（fMRI）和光学固有 信号（OIS）和通过皮层刺激获得的运动地图。 通过研究一组接受清醒开颅手术的患者， 有一个独特的机会来验证非侵入性映射技术， 直接测量皮层 这将有助于建立 功能磁共振成像在术前定位中的作用，并为研究奠定基础 在神经系统疾病中恢复人类运动功能。 具体目标 假设1：控制手臂和手的人类初级运动皮层 运动的特征在于功能相关的重叠区域， 这将通过fMR.1和光学内在信号传导来证明。 假设2：初级运动皮层地图之间的差异 通过直接皮层刺激获得，fMR 1和OIS将引起 为了更好地理解 这些信号，并最终更好地定位皮质 手术患者的功能。 假设3：初级运动皮层 在想象的运动中激活。

The goal of this project is to examine the functional organization of human primary motor cortex controlling hand and arm movements. By using multiple imaging modalities we will determine the relationship between activations in primary Motor cortex. as measured by functional magnetic resonance imaging (fMRI) and optical intrinsic signaling (OIS), and the motor map obtained by cortical stimulation. By studying a group of patients undergoing awake craniotomy we will have a unique opportunity to validate non-invasive mapping techniques with direct cortical measurements. This will serve to establish the role of fMRI in presurgical mapping and lay the foundation for studies of recovery of human motor function in neurological disease. Specific Aims Hypothesis 1: Human primary motor cortex controlling arm and hand movement is characterized by functionally related overlapping regions, which will be demonstrable by fMR.1 and optical intrinsic signaling. Hypothesis 2: Discrepancies between the maps of primary motor cortex obtained by direct cortical stimulation, fMR1 and OIS will give rise to a better understanding of the physiologic properties underlying these signals and ultimately to better localization of cortical function in surgical patients. Hypothesis 3: Primary motor cortex is activated during imagined movements.